Trypanosoma cruzi has been subdivided into seven Discrete Typing Units (DTUs), TcI-TcVI and Tcbat. Two major evolutionary models have been proposed to explain the origin of hybrid lineages, but while it is widely accepted that TcV and TcVI are the result of genetic exchange between TcII and TcIII strains, the origin of TcIII and TcIV is still a matter of debate. T. cruzi satellite DNA (SatDNA),...

The recent demonstration of the occurrence in rat brain and other nonpancreatic tissues of carboxypeptidase A (CPA) gene transcripts without associated catalytic activity could be ascribed to the presence of a soluble endogenous protein inhibitor. This tissue carboxypeptidase inhibitor (TCI), detected by the inhibition of added bovine pancreatic CPA, was purified from rat brain. Peptides were o...

INTRODUCTION This work presents the initial findings of a molecular epidemiological investigation of Trypanosoma cruzi in triatomine insects in State of Mato Grosso do Sul. METHODS A total of 511 triatomines from different regions of the state were examined. Deoxyribonucleic acid (DNA) was extracted from the intestinal contents of the insects using phenol-chloroform-isoamyl alcohol (25:24:1)....

Drought has been identified as one of the significant complicated natural disasters exacerbated by land degradation and climate change. Hence, monitoring drought evaluating its spatiotemporal dynamics are essential to manage regional conditions protecting environment. In this study, various single remote sensing-based indices including soil moisture condition index (SMCI), precipitation (PCI), ...

The goals of this study were to find the average intracranial capacity of the living male-entities of Kosovo Albanian population, to define cephalofacial indexes and their interrelations with intracranial capacity and to explore their latent structure. Eight cephalofacial variables have been measured in 571 male entities of the Kosovo Albanian population, aged 18-35 years old. Of these measurem...

The matrix converter (MC) is a direct ac–ac power featuring high density and efficiency. However, the conventional MC (CMC) topologies require control complexity transistor capacity, hindering wide applications. An emerging topology (3CI-MC) based on third-harmonic current injection (3CI) reduces complexity, but requires more transistors complex clamping circuit. This article proposes trapezoid...

The Teladorsagia circumcincta P-glycoprotein-9 (Tci-pgp-9) gene has previously been implicated in multiple-anthelmintic resistance in this parasite. Here we further characterise genetic diversity in Tci-pgp-9 and its possible role in ivermectin (IVM) and multi-drug resistance using two UK field isolates of T. circumcincta, one susceptible to anthelmintics (MTci2) and the other resistant to most...

This systematic literature review maps the evidence for the effectiveness of the therapeutic community interventions (TCI) in reducing re-arrest, re-incarceration or drug misuse following release from prison, including the extent to which these effects are retained over time. The databases searched for the review included PsychINFO, Medline and Scopus and reference lists from relevant articles ...

Topical calcineurin inhibitors (TCI) are a relatively new class of drugs used in dermatology. There are two drug forms available - tacrolimus 0.03% or 0.1% ointment and 1.0% pimecrolimus cream. The drugs act by inhibiting synthesis of proinflammatory cytokines. The only approved indication for using TCI is treatment of atopic dermatitis. The TCI may be used as an alternative therapy to corticos...

BACKGROUND Cerebral state index (CSI) has recently been introduced as an intra-operative monitor of anaesthetic depth. We compared the performance of the CSI to the bispectral index (BIS) in measuring depth of anaesthesia during target-controlled infusion (TCI) of propofol. METHODS Twenty Chinese patients undergoing general anaesthesia were recruited. CSI and BIS, and predicted effect-site co...