OBJECTIVE In this prospective study we investigated the role of plasma levels of soluble urokinase plasminogen activator receptor (suPAR) in children with urinary tract infection. MATERIAL AND METHODS We measured the levels of plasma suPAR during admission in 42 children with suspected acute pyelonephritis and compared the results to acute DMSA scintigraphy. RESULTS The mean level of plasma...

Meso-2,3-dimercaptosuccinic acid (DMSA, or succimer) is an oral chelating agent for heavy-metal poisoning. While studying the urinary elimination of unaltered DMSA, altered DMSA (i.e., its mixed disulfides), and lead in children with lead poisoning, we observed a pattern of urinary drug elimination after meals suggestive of enterohepatic circulation. The excretion of lead in urine patterned the...

To identify the frequency of voiding dysfunction in patients with functional constipation, dysfunctional voiding soring system (DVSS) was surveyed in 85 patients with functional constipation. Urinalysis, culture and renal ultrasound were performed in all cases. If the child had urinary tract infection, voiding cystourethrography and DMSA scan were performed. Fifty four patients (63.5%) out of 8...

Objective—To evaluate the role of vitamin A on renal scarring in recurrent urinary tract infections (UTIs). Design—Twenty three children with UTIs and renal scarring (mean (SD) age 7.3 (3.9) years) and 91 children without renal scarring (6.4 (3.4) years) were studied. All the children had serum vitamin A and â-carotene measurements and nutritional evaluation. Renal scarring was assessed by tech...

PURPOSE Intrarenal reflux (IRR) occurs in 3-10% of cases of total reflux and can lead to renal injury, which may eventually result in renal scarring. In this study, we evaluated the clinical importance of IRR detected by voiding cystourethrography and evaluated the relationship between IRR and renal scarring. MATERIALS AND METHODS From January 2002 to May 2008, 50 patients who were diagnosed ...

OBJECTIVE This study aims to determine if normal absolute uptake values of dimercaptosuccinic acid (DMSA) can be predicted accurately over the optimal time for imaging. METHODS Eighty-eight normal kidneys were analyzed from 44 children with a median age of 4 y. The mean time between injection and scan was 171.7 min. The absolute uptake of DMSA in milligrams was calculated for each kidney. R...

INTRODUCTION The role of vitamin A in re-epithelialization of the damaged mucosal surfaces has been documented. The aim of this study was to evaluate the role of vitamin A in preventing renal scaring after acute pyelonephritis in children. MATERIALS AND METHODS This clinical trial study was conducted in children with acute pyelonephritis in Mofid Children Hospital (Tehran, Iran). Patients wer...

OBJECTIVE To apply a semiquantitative method for analysis of technetium-99m-dimercaptosuccinic acid ((99m)Tc-DMSA) renal scintigraphy for monitoring the effect of extracorporeal piezoelectric lithotripsy (EPL) in patients with calyceal stones on regional kidney function and to check whether EPL had caused any deleterious effect on the target calyceal renal parenchymal function. PATIENTS AND M...

(99m)Tc dimercaptosuccinic acid (DMSA) renal scans can provide accurate diagnosis of acute pyelonephritis, its sequelae (renal scars) and differential renal function (DRF). The purposes of this retrospective study were (1) to assess the relationship between DRF obtained during acute pyelonephritis and at follow-up, and (2) to elucidate the value of initial DRF in predicting subsequent renal sca...