We present a case that used argon plasma coagulation (APC) for the healing of bronchopleural fistulas (BPF), which most probably developed secondary to tracheobronchial anastomotic failure (TBAF). We aimed to show this procedure as an alternative treatment for the small fistulas that could develop after pneumonectomy. In a 56-year old male patient, right upper lobe squamous cell carcinoma was d...

A novel synthetic pathway for trifluoromethylthioferrocene (3), which does not involve the use of toxic mercury(II)-based reagents, is described. The novel approach involves first the treatment of the commercially available bromoferrocene (1a) with NaSCN in the presence of copper(+I) to yield thiocyanatoferrocene (1), and then the reaction of 1 with the Rupper-Prakash reagent and tetrabutylammo...

A novel synthetic pathway for trifluoromethylthioferrocene (3), which does not involve the use of toxic mercury(II)-based reagents, is described. The novel approach involves first the treatment of the commercially available bromoferrocene (1a) with NaSCN in the presence of copper(+I) to yield thiocyanatoferrocene (1), and then the reaction of 1 with the Rupper-Prakash reagent and tetrabutylammo...

Flow-focusing microfluidic techniques were used to provide access to core−shell microcapsules in which the shell is composed of end-capped poly(phthalaldehydes) that depolymerize completely from head-to-tail in response to fluoride. Microcapsules made from these depolymerizable polymers provide an amplified response to the applied chemical signal, where the rate of the response can be tuned bot...

g-Pyrone natural products are an important class of compounds that exhibit a wide range of biological activity. Similarly, indole-containing compounds are found throughout nature as well as in pharmaceuticals and agrochemicals. Recently, Kam and co-workers isolated pleiomaltinine 1 (Scheme 1), an unusual alkaloid-pyrone natural product that is able to reverse multidrug resistance in vincristine...

The structure of the chromophore component of the cytotoxic protein-chromophore complex kedarcidin was determined by researchers at BMS in 1992 on the basis of an extensive spectroscopic analysis of the isolated chromophore and its degradation products, an undertaking that was greatly complicated by the reactivity of the chromophore and its low natural abundance.1 The original structural propos...

Lewis acid-catalyzed reaction of allyl and benzyl trichloroacetimidates with r-silyl alcohols was found to be a general method for the synthesis of r-alkoxysilanes. Upon exposure to CsF, these r-alkoxysilanes could be made to undergo [2,3]-Wittig rearrangement with an efficiency similar to that realized by the analogous but inherently more toxic r-alkoxystannanes. For over 20 years Wittig rearr...

The neoclerodane diterpene salvinorin A (1) was isolated in 1982 from the rare mint SalVia diVinorum, indigenous to Oaxaca, Mexico.1 Recent efforts established salvinorin A as a potent and selective κ opioid receptor agonist, the only non-alkaloid psychoactive substance, and the most potent naturally occurring hallucinogen.2 As a result of its therapeutic potential, renewed isolation efforts ha...

found in amphibian skin, and the 5,8-disubstituted indolizidines, one of the largest subclass of these alkaloids, were detected from skin extracts of the poison-frog. Quite recently, we have found the synthetic 5,8-disubstituted indolizidine 235B (1), isolated from Dendrobates pumilio, acted as a potent noncompetitive and selective blocker of a4b2 nicotinic receptor (IC50 74 nM). The sensitivit...