The presence of even mild renal insufficiency is usually associated with an increased rate of cardiovascular events after coronary stenting. The aim of this study was to evaluate the impact of mild to moderate renal insufficiency on the chronic vascular responses to the implantation of paclitaxel-eluting stents (PES; Taxus) and bare-metal stents (BMS). In the TAXUS IV, TAXUS V, and TAXUS VI tri...

Two new taxoids called 7,13-dideacetyl-9,10-debenzoyl-7beta,9alpha-p-hydroxylbenzylidenedioxy-taxchinin C (1) and 7,13-dideacetyl-2,9,10-debenzoyl-2-tigloyl-7beta,9alpha-p-hydroxylbenzylidenedioxy-taxchinin C (2) were isolated from the leaves and stems of Taxus chinensis. They represent the first examples of taxoids containing the 5/7/6-membered ring system with 7beta,9alpha-p-hydroxylbenzylide...

Erratum In the original publication [1] the species name Kutki (Neopicrorhiza scrophulariiflora) is wrongly mentioned as CITES listed species. The correct version of the sentence in the second paragraph of “Threats and conservation challenges” can be found here: Illegal trade of NTFPs from the landscape often includes some of the CITES Appendix listed species such as Sunakhari (Orchids) and Lau...

Black vine weevils, Otiorhynchus sulcatus (F.) (Coleoptera: Curculionidae), are serious pests of container- and field-grown nursery crops. Management programs usually target the larval stage in container-grown plants and the adults in field-grown plants. We tested several new systemic insecticides for efficacy against black vine weevil in container-grown Sedum spp. and field-grown Taxus spp. In...

OBJECTIVES This study was conducted to determine whether direct stenting with TAXUS Liberté is noninferior to stenting after pre-dilation. BACKGROUND Direct stenting is performed in approximately 30% of patients, but data on clinical and angiographic outcomes with drug-eluting stents are limited. METHODS The TAXUS ATLAS DIRECT STENT is a single-arm, multicenter study that enrolled patients ...

BACKGROUND Despite the availability of several studies to clarify taxonomic problems on the highly threatened yews of the Hindu Kush-Himalaya (HKH) and adjacent regions, the total number of species and their exact distribution ranges remains controversial. We explored the use of comprehensive sets of morphological, molecular and climatic data to clarify taxonomy and distributions of yews in thi...

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Taxus cell suspension culture is a sustainable technology for the industrial production of paclitaxel (Taxol®), a highly modified diterpene anti-cancer agent. The methyl jasmonate (MJ)-mediated paclitaxel biosynthetic pathway is not fully characterized, making metabolic engineering efforts difficult. Here, promoters of seven genes (TASY, T5αH, DBAT, DBBT, PAM, BAPT, and DBTNBT), encoding enzyme...