There is a compelling need to develop anticancer therapies that target cancer cells and tissues. Arising from innovative femtomedicine studies, a new class of non-platinum-based halogenated molecules (called FMD molecules) that selectively kill cancer cells and protect normal cells in treatments of multiple cancers has been discovered. This article reports the first observation of the radiosens...

Abstract Background Despite current advances in systemic therapy for brain metastases, neurosurgery remains the preferred method of choice patients with limited metastases. Postoperative radiotherapy indicated to reduce risk local recurrence is recommended all after surgery. The aim this retrospective study describe clinical characteristics and survival outcomes consecutive cohorts treated by c...

Abstract AIMS Imaging of tumour habitats is a novel technique to assess regional treatment response by defining ‘habitats’, which are regions with shared imaging characteristics. Here, we describe pipeline characterise in glioblastoma using bioinformatics and machine learning. We apply this patients the Preoperative Brain Irradiation Glioblastoma (POBIG) trial that received preoperative radioth...

In the past 20 years, the classic paradigm in radiobiology recognizing DNA as the main target for the action of radiation has changed. The new paradigm assumes that both targeted and non-targeted effects of radiation determine the final outcome of irradiation. Radiotherapy is one of the main modality treatments of neoplastic diseases with intent to cure, or sometimes to palliate only, thus radi...

Ovarian cancer is the most lethal of the gynecologic cancers, with 5-year survival rates less than 50%. Most women present with advanced stage disease as the pattern of spread is typically with dissemination of malignancy throughout the peritoneal cavity prior to development of any symptoms. Prior to the advent of platinum-based chemotherapy, radiotherapy was used as adjuvant therapy to sterili...

Radiations in medicine cover a wide range of applications, predominantly diagnostic imaging and radiotherapy, encompassing photons (x- γ-rays) particle radiation, as well with the use liquid sources nuclear focusing on physiological functional imaging, tumour detection or targeted radiotherapy. The biological interactions ionizing radiation leads naturally to questions benefits risk following d...

Pneumothorax is defined as air in the pleural space. Depending on the severity of the pneumothorax, treatment consists of oxygen therapy, simple aspiration, tube thoracostomy, and pleurodesis. Prolonged air leakage is observed in 25% of the patients who have undergone surgical procedures, such as thoracotomy, pleurectomy, and video-assisted thoracoscopy. The patient presented here is the third ...

Targeted radionuclide therapy is an alternative method of radiation treatment which uses a tumor-seeking agent carrying a radioactive atom to deposits of tumor, wherever in the body they may be located. Recent experimental data signifies promise for the amalgamation of gene transfer with radionuclide targeting. This review encompasses aspects of the integration of gene manipulation and targeted...

Most cancer patients are treated with radiotherapy, but the treatment can also damage the surrounding normal tissue. Radiotherapy side-effects diminish patients' quality of life, yet effective biological interventions for normal tissue damage are lacking. Protecting microvascular endothelial cells from the effects of irradiation is emerging as a targeted damage-reduction strategy. We illustrate...

In the last one and half decade, Lu has emerged as one of the most important and useful radionuclides for the development of a wide variety of targeted radiotherapy agents owing to its suitable nuclear decay characteristics, comparatively longer half-life and production feasibility using medium flux research reactors. Radiopharmaceuticals Division (RPhD), BARC has done pioneering work in the fi...