Androgen receptor (AR) gene mutations have been shown to cause androgen insensitivity syndrome with altered sexual differentiation in XY individuals, ranging from a partial insensitivity with male phenotype and azoospermia to a complete insensitivity with female phenotype and the absence of pubic and axillary sexual hair after puberty. In this study we present an 11-yr-old XY girl, with clinica...

SIMPLE (Superheated Instrument for Massive ParticLE searches) employs superheated droplet detectors (SDDs) to search for Weakly Interacting Massive Particle (WIMP) dark matter. As a result of the intrinsic SDD insensitivity to minimum ionizing particles and high fluorine content of target liquids, competitive WIMP limits were already obtained at the early prototype stage. We comment here on the...

Plant microRNAs (miRNAs) typically form near-perfect duplexes with their targets and mediate mRNA cleavage. Here, we describe an unconventional miRNA target of miR398 in Arabidopsis, an mRNA encoding the blue copper-binding protein (BCBP). BCBP mRNA carries an miR398 complementary site in its 5'-untranslated region (UTR) with a bulge of six nucleotides opposite to the 5' region of the miRNA. De...

New preliminary data from the U.S. Department of Health and Human Services (HHS) showed a 9 percent decrease in patient injuries in hospitals in 2012 compared with a 2010 baseline, and an 8 percent decrease in Medicare fee-for-service 30-day readmissions.2 The data also showed improvement on a range of measures for health care-associated infections (HAIs) and conditions, including for SSIs. HEN...

We consider a symmetric simple random walk {Wi} on Z, d = 1, 2, in which the walker may choose to stand still for a limited time. The time horizon is n, the maximum consecutive time steps which can be spent standing still is mn and the goal is to maximize P (Wn = 0). We show that for d = 1, if mn (logn) for some γ > 0, there is a strategy for each n yielding P (Wn = 0) → 1. For d = 2, if mn n f...

Yi Xiong obtained his PhD degree in bioinformatics from Wuhan University, China, in 2011. He worked as a research assistant at the Department of Bioinformatics and Biostatistics in Shanghai Jiao Tong University, China, from 2009 to 2011. He is currently working as a postdoctoral research associate at the Department of Biological Sciences, Purdue University (IN, USA). He has published several sc...

DGK-ζ is a negative regulator of TCR signaling that causes degradation of the second messenger DAG, terminating DAG-mediated activation of Ras and PKCθ. Cytotoxic T cells deficient in DGK-ζ demonstrate enhanced effector functions in vitro and antitumor activity in vivo, perhaps because of insensitivity to inhibitory cytokines. We sought to determine whether the enhanced responsiveness of DGK-ζ-...

INTRODUCTION Androgen is a generic term usually applied to describe a group of sex steroid hormones. Androgens are responsible for male sex differentiation during embryogenesis at the sixth or seventh week of gestation, triggering the development of the testes and penis in male fetuses, and are directed by the testicular determining factor: the gene SRY (sex determining region on Y chromosome) ...