Background: Type 2 diabetes mellitus that characterized by insulin resistance and it is a risk of many diseases the impact genetic factors on well documented. Vitamin D receptor (VDR) gene polymorphisms have been linked to T2DM. In this study, we analyzed relation between TaqI ApaI VDR T2DM subjects using PCR-RFLP method in Kurdish patients.

Source and Description: G2—2 E is a single copy 200 bp subfragment of G2 cloned into the EcoRV site of Bluescript KSII(+). Clone G2 was isolated from a library highly enriched for (TTAGGG)n-associated sequences (1). Polymorphisms: TaqI identifies a two allele polymorphism as assessed in 29 unrelated Caucasians. Allele Size No. of Chromosomes Frequency Al 900 bp 31 (0.54) A2 700 bp 27 (0.46) Pst...

Vitamin D deficient rickets is prevalent in Turkey and a considerable number of children are at risk of growth retardation, impaired bone formation and fracture. In order to check whether vitamin D receptor (VDR) gene polymorphism relates to the vitamin D deficient rickets, we analyzed VDR gene FokI, TaqI and ApaI polymorphisms in 24 Turkish vitamin D deficient rickets patients and 100 healthy ...

A cDNA for coagulation factor XII has been used to investigate the presence of gene lesions and restriction fragment length polymorphisms in two brothers with Hageman trait and their family. A TaqI polymorphic fragment has been found in the two propositi and in 11 members of the paternal lineage. This polymorphism, absent in the normal population, is correlated with the reduction of factor XII ...

Bovine leukocyte adhesion deficiency (BLAD) is a genetically transmitted disease and inherited as an autosomal recessive defect. Keeping this in view the present study was conducted to estimate incidence of carrier animals in a herd of breeding bulls for mutation in Integrin â2 gene, reared at Frozen Semen Bull Station (FSBS), Haringhata, Nadia, West Bengal, India. A total of 80 bulls of differ...

SOURCE/DESCRIPTION: A 4.0 kb TaqI fragment of cosmid EFD64 isolated by a HBV-3 oligonucleotide (1) was subcloned into AccI site of pUC18. POLYMORPHISM: Mspl identifies 5 allelic VNTR polymorphism with bands between 2.6 and 4.6 kb. Rsal, TaqI, EcoRI, BamHI, Hindlll and Pvull identify the same VNTR polymorphism. FREQUENCY: With Rsal, 80 % heterozygosity were observed in 80 unrelated Caucasians. N...

Cystic fibrosis (CF) is the most common severe autosomal recessive disease in Caucasoid population caused by mutations CF transmembrane regulator ( CFTR ) gene. However, course of may be modulated genetic factors other than gene and pleiotropically influenced VDR Vitamin D Receptor The aim study was to search for associations between variants (c.1206T>C(A>G), c.152T>C, c.1174+283G>A...