Epidemiologic studies suggested that vitamin E has a protective effect against prostate cancer. We showed here that tocopherol-associated protein (TAP), a vitamin E-binding protein, promoted vitamin E uptake and facilitated vitamin E antiproliferation effect in prostate cancer cells. Interestingly, without vitamin E treatment, overexpression of TAP in prostate cancer cells significantly suppres...

We present what we believe to be the first formal verification of a biologically realistic (nonlinear ODE) model of a neural circuit in a multicellular organism: Tap Withdrawal (TW) in C. Elegans, the common roundworm. TW is a reflexive behavior exhibited by C. Elegans in response to vibrating the surface on which it is moving; the neural circuit underlying this response is the subject of this ...

Accurate temporal information processing is critically important in many motor activities within disciplines such as dance, music, and sport. However, it is still unclear how temporal information related to biological motion is processed by expert and non-expert performers. It is well-known that the auditory modality dominates the visual modality in processing temporal information of simple sti...

BACKGROUND The transporter associated with antigen processing (TAP) supplies cytosolic peptides into the endoplasmic reticulum for binding to major histocompatibility complex (MHC) class I molecules. Its specificity therefore influences the repertoire of peptides presented by MHC molecules. Compared to human TAP, murine TAP's binding specificity has not been characterized as well, even though m...

Published sealed-bid auction schemes are classi ed into four models according to how they deal with bid privacy. The properties of each model are introduced and possible improvements in these models are suggested. A new model is proposed and its implementation is discussed. Application of di erent models is discussed, based on a comparison of the models.

W H E N the Manhigh capsule system was being designed in the fall of 1955, the pr imary objective was a maximum performance system of minimum weight that could lift a man into a space equivalent environment for twenty-four hours. This objective 'had to be met safely and supply an answer to what the man could :do if any specific componem failed. Beyond this, an effort was made to provide him wit...

We have N = {1, . . . , n} bidders, where each bidder has a private valuation vi drawn from distribution Fi 1 with strictly positive den1 Here, we assume that valuations follow the IPV model. sity, fi : Ti → R>0, for a good up for sale by the auctioneer, agent 0. In a first-price, sealed-bid auction, each agent has a type vi ∈ Ti, and submits a bid bi to the auctioneer, without revealing what t...

Consider a protocol in which Belinda seals a (classical) message. She gives the resulting sealed message to Charlie, who can either unseal and read the message or return it unopened to Belinda. If he returns it unopened, Belinda should be able to verify that Charlie neither read the message nor made a copy that would allow him to read it later. Such a protocol is impossible with classical crypt...