Transcription activator-like effectors (TALEs), secreted by the pathogenic bacteria Xanthomonas, specifically activate expression of targeted genes in plants. Here, we designed synthetic TALEs that bind to the flanking regions of the TATA-box motif on the CaMV 35S promoter for the purpose of understanding the engineerable 'hot-spots' for increasing transgene expression. We demonstrated that tra...

Plant pathogenic bacteria of the genus Xanthomonas possess transcription activator-like effectors (TALEs) that activate transcription of disease susceptibility genes in the host, inducing a state of disease. Here we report that some isolates of the rice pathogen Xanthomonas oryzae use truncated versions of TALEs (which we term interfering TALEs, or iTALEs) to overcome disease resistance. In com...

In what case do you like reading so much? What about the type of the beautiful teams inspiring and cautionary tales from veteran team leaders book? The needs to read? Well, everybody has their own reason why should read some books. Mostly, it will relate to their necessity to get knowledge from the book and want to read just to get entertainment. Novels, story book, and other entertaining books...

Transcription activator-like effectors (TALEs) are secreted by plant-pathogenic Xanthomonas bacteria into plant cells where they act as transcriptional activators and, hence, are major drivers in reprogramming the plant for the benefit of the pathogen. TALEs possess a highly repetitive DNA-binding domain of typically 34 amino acid (AA) tandem repeats, where AA 12 and 13, termed repeat variable ...

CONCRETE, OR AUTISTIC? ALGIMANTAS M. SHIMKUNAS, MALCOLM D. GYNTHER, AND KATHLEEN SMITH Washington University School of Medicine Psychopathology was more effective in predicting autistic responses to proverbs of acutely ill schizophrenic patients than was intelligence as measured by the Wechsler Vocabulary subtest. Autistic responses decreased significantly from preto post-S wk. of hospital trea...

The connection of the category death is considered in context natural, economic, social, spiritual existence a peasant. Subjective and objective factors influencing idea are analyzed. dependence peasant life on environment revealed, since nature occupies special place structure mentality. article contains proverbs, sayings from fairy tales, confirming that an individual was unsteady, constantly...

Once upon a time in faraway places, stories were told around campfires and hearths among family and friends. Eventually these oral stories were written down and some were illustrated. Two of the best-known names in written folk literature are the Frenchman Charles Perrault and the Grimm Brothers of Germany. In 1697 Perrault published a collection entitled Tales of Mother Goose, and from 1812 to...

Previous research suggests that members of East Asian cultures show a greater preference for dialectical (vs. nondialectical) thinking than do members of Western Cultures. We suggest this difference is rooted in a greater chronic fear of isolation (FOI) in East Asians than in Westerners. To explain this hypothesis, we manipulated fear of isolation in a group of Western college students and asse...

Plant-pathogenic Xanthomonas bacteria inject transcription activator-like effector proteins (TALEs) into host cells to specifically induce transcription of plant genes and enhance susceptibility. Although the DNA-binding mode is well-understood it is still ambiguous how TALEs initiate transcription and whether additional promoter elements are needed to support this. To systematically dissect pr...