7-Ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of antitumor agent irinotecan (CPT-11), is conjugated and detoxified to SN-38-glucuronide by UDP-glucuronosyltransferase (UGT) 1A1. Genetic polymorphisms in UGT1A1 are thought to contribute to severe diarrhea and/or leukopenia caused by CPT-11. In this regard, it has been reported that polymorphisms in the promoter region could affect...

Healthy young men were fed four diets for 2 weeks each providing natural fats containing palmitic acid (16 : 0) predominantly in the sn-1, 3 position of dietary TAG or containing 16 : 0 predominantly in the sn-2 position with low or high levels of linoleic acid (18 : 2n-6). Two treatments supplied 16 : 0 in the sn-1, 3 positions from palmstearin with low (3 % energy) or high (>7 % energy) 18 : ...

the velocity data of seismic waves in a region has an important role in locating occurred events. information such as velocity ratio of vp/vs and velocity curves for pg, pn, sg, and sn phases directly affect the locating results. it is well known that the vp/vs ratio can be used to predict lithology, and that s-waves are sensitive to microcracks aligned by the present day stress field. also, th...

In this paper we map out the 1300 8C isothermal section in the Nb–Sn–C ternary system. The results show that the only ternary compound in the system, Nb SnC, is in equilibrium with Sn, NbC , and Nb Sn, but not with Nb, Nb C or C. The Nb SnC phase is not a 2 x 3 2 2 stoichiometric compound but exists over a range of compositions that range from an Nb:Sn:C ratio of |54:22:24 at.%, when in equilib...

The interaction of anticancer drug Sn (CH3)2(N-acetyl-L-cysteinate) with carbon nanotube (CNT)is investigated by Quantum chemical ab initio calculations at FIF/ (LanL2DZ+STO-3G) and HF/(LanL2DZ+6-31G) levels in gas phase and solution. The solvent effect is taken into account viathe self-consistent reaction field (SCRF) method. Carbon nanotubes can act as a suitable drugdelivery vehicle for inte...

We determined the distribution of lecithin molecular species between vesicles and mixed micelles in cholesterol super-saturated model biles (molar taurocholate-lecithin-cholesterol ratio 67:23:10, 3 g/dl, 0.15 M NaCl, pH approximately 6-7) that contained equimolar synthetic lecithin mixtures or egg yolk or soybean lecithins. After apparent equilibration (48 h), biles were fractionated by Supero...

In this research, first, nanoparticles of SrFe11.98Mg0.1Sn0.1O19 hexaferrite was synthesized via sol-gel auto-combustion process and then the nanocomposites of hexagonal ferrites/perovskite with the amounts of SrFe11.98Mg0.1Sn0.1O19/BaTiO3 (50/50, 40/60, 70/30 w/w) was prepared by the ball-milling...

Given a convex polygon P in the plane and a positive integer n, we consider the problem of generating a length-uniform triangular mesh for the interior of P using n Steiner points. More specifically, we want to find both a set Sn of n points inside P , and a triangulation of P using Sn, with respect to the following minimization criteria: (1) ratio of the maximum edge length to the minimum one,...

We have developed a new diagnostic tool for the study of gamma-ray emission lines from radioactive isotopes (such as 26Al and 60Fe) in conjunction with other multiwavelength observables of Galactic clusters, associations, and alike objects. Our evolutionary synthesis models are based on the code of Cerviño & Mas-Hesse (1994), which has been updated to include recent stellar evolution tracks, ne...

We report the synthesis and characterization of Cu2ZnSnS4 (CZTS) with controlled phase purity. The precursor was first prepared using sequential electrodeposition of Cu, Zn, and Sn in different orders. The Cu/(Sn+Zn) ratio in each stacking order was also varied. The precursor was subjected to annealing at 200°C and sulfurization at 500°C in a 5%-H2S/Ar atmosphere for the formation of CZTS. The ...