Laboratorialmente, o quadro de hemólise ocasionado pela doença hemolítica do feto e recém-nascido (DHFRN) pode ser evidenciado pelo resultado positivo teste da antiglobulina direto (TAD) detecção anticorpos antieritrocitários anti-A anti-B realizada através eluato. No presente trabalho buscou-se levantar a prevalência presentes em casos incompatibilidade ABO materno-fetal relacionar com clínica...

In recent years, proposed studies on time-series anomaly detection (TAD) report high F1 scores benchmark TAD datasets, giving the impression of clear improvements in TAD. However, most apply a peculiar evaluation protocol called point adjustment (PA) before scoring. this paper, we theoretically and experimentally reveal that PA has great possibility overestimating performance; even random score...

Topologically associated domains (TADs) are 3D genomic structures with high internal interactions that play important roles in genome compaction and gene regulation. Their genomic locations and their association with CCCTC-binding factor (CTCF)-binding sites and transcription start sites (TSSs) were recently reported. However, the relationship between TADs and other genomic elements has not bee...

We have previously described a dominant-negative mutant of cJun that lacks the transactivation domain (TAD) of cJun and prevents AP-1-mediated transcriptional activation by quenching endogenous Jun or Fos proteins. We now report the development of a panel of cJun mutants that have inactivating mutations in the TAD, DNA-binding domain (DBD), or leucine zipper domain. These mutants are all unable...

The N-terminal acidic transactivation domain (TAD) of ERM/ETV5 (ERM38-68), a PEA3 group member of Ets-related transcription factors, directly interacts with the ACID/PTOV domain of the Mediator complex subunit MED25. Molecular details of this interaction were investigated using nuclear magnetic resonance (NMR) spectroscopy. The TAD is disordered in solution but has a propensity to adopt local t...

BACKGROUND To explore the impact of patient-characteristics and relevant comorbidities on treatment continuation rates, effectiveness, and satisfaction in patients with erectile dysfunction (ED) who started or switched to tadalafil 5 mg once daily (TAD-OaD) at baseline. METHODS In the EDATE observational study, phosphodiesterase-type-5 (PDE5)-inhibitor pretreated or naïve ED patients who star...

BACKGROUND Associated tricuspid annuloplasty is recommended during left-heart valve surgery when the tricuspid annulus (TA) is dilated but methodology for the measurement of TA size and thresholds for TA enlargement are not clearly defined. METHODS AND RESULTS Measurement of the TA diameter (TAD) was prospectively performed using 2-dimensional transthoracic echocardiography (2D-TTE) in 282 pa...