Selegiline orally disintegrating tablet is a potent, selective and irreversible inhibitor of monoamine oxidase type B. It is delivered in an innovative formulation that largely bypasses the gut and first-pass hepatic metabolism by allowing transbuccal absorption. Selegiline orally disintegrating tablet dissolves in the mouth within seconds and is rapidly absorbed directly into the systemic circ...

The present invention relates to multiple-unit tablet dosage forms, which is composed of several subunits (multiparticulates/pellets). Each small multiparticulate further composed of many layers. Some layer contains drug substance; others are rate controlling polymer. The resulting multiple-unit tablet dosage forms of pantoprazole were satisfactory fabricated. Pelletization technique has some a...

A double-blind cross-over trial was conducted to assess the effects of salbutamol administered by inhalation of dry powder, by tablet, and combined tablet and inhalational powder in a sample of 18 severely asthmatic children. The combined treatment had a rapid onset of effect and sustained action. The onset of action of the tablet treatment was less rapid but sustained, whereas the inhalational...

In this study, we examined a possible use of a surface-deacetylated chitin nano-fiber (SDCH-NF) and hyaluronic acid (HA) interpolymer complex (IPC) tablet as a potential antioxidative compound in extended-release matrix tablets. The antioxidant properties of untreated chitin (UCH), SDCH-NF, and HA were examined using N-centered radicals derived from 1,1'-diphenyl-2-picrylhydrazyl (DPPH) and 2,2...

Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical properties of lisinopril tablets as a result of splitting the tablets either by hand or with a splitting device. The impact of the splitting technique of lisinopril (Zestril® tabl...

Almorexant, a dual orexin receptor antagonist, was investigated for the treatment of insomnia. The following observations initiated further formulation development: the active pharmaceutical ingredient (API) was sticking to the apparatus used during tablet compression; almorexant has an absolute bioavailability of 11.2%; and almorexant modestly decreased the latency to persistent sleep by 10.4 ...

BACKGROUND Aluminum Phosphide or rice tablet is one of the most common pesticides which leads to accidental or intentional acute intoxication and finally death. In this paper, we describe a successful management of intoxication with rice tablet in a young girl. CASE PRESENTATION A 14-year-old girl was admitted due to consumption of rice tablet. Gastric washing with two vials of sodium bicarbo...

Tablet PC's are traditional notebook computers with the ability to process digital ink by writing with a stylus. They have recently attracted attention as a potential tool for educational use. This paper describes the author’s experience using the Tablet PC to conduct a CS1 course and a software engineering (SWE) course. The SWE course consisted primarily of PowerPoint lectures while the CS1 co...

Shifts from print media to electronic media may be regarded as a possibility for promoting sustainability. However, the benefits of electronic media are not unquestioned. Previous studies on the environmental impacts of print and electronic media have shown that there is no easy answer. Contributing to this field of research, the present study sought to assess the climate change impact of the t...

In present study, mucoadhesive vaginal tablet of sertaconazole was designed using a combination of mucoadhesive polymers like Carbopol 934P, chitosan, carboxymethylcellulose sodium, sodium alginate, methyl cellulose, hydroxypropyl methylcellulose and hydroxypropyl cellulose. Effervescent was incorporated into formulations to enhance swellabilty of mucoadhesive tablet. For various drug-free form...