The effects of mixtures Ni–Ta and Ni–Zr powders combined with sintered solid solution TaB2 –NbC during spark-plasma sintering compositions at a pressing loading 60 MPa in the range 1200 – 1600°C on phase composition, percent content Ti, Ta, Zr sialon; microstructure; grain sizes crystalline phases; relative density; linear shrinkage; physical-mechanical properties; correlation elasticity modulu...

Background: Head and neck squamous cell carcinoma (HNSCC) is a devastating disease that has generally poor prognosis. Cisplatin-based therapies remain the standard of care for these patients, however, many patients experience acute toxic effects develop resistance to treatment. Polyamine metabolism been shown promote growth cancer cells. AMXT-1501 compound in clinical trials inhibits polyamine ...