Phage T4 has provided countless contributions to the paradigms of genetics and biochemistry. Its complete genome sequence of 168,903 bp encodes about 300 gene products. T4 biology and its genomic sequence provide the best-understood model for modern functional genomics and proteomics. Variations on gene expression, including overlapping genes, internal translation initiation, spliced genes, tra...

In 327 newborns cord blood thyroxine (T4) was 11.8 +/- 0.4 mug/100 ml (SEM) (151.9 +/- 5.1 nmol/l), and serum thyrotrophin (TSH) 6.7+/-1.0 muU/ml. Variability was marked for both T4 and TSH. Remeasured in the same patients on the fifth day of life, the TSH level was 3.7 +/- 1.0 muU/ml, lower than at birth (P less than 0.001), while scattering of TSH values was much smaller, with 99.4 % of value...

Objectives: The purpose of this study is to evaluate the anesthesia methods by observing hemodynamic changes, oxygen supply and demand balance in order to provide the reference for the Off-Pump Coronary Artery Bypass Grafting (OPCABG) anesthesia management level during OPCABG. Methods: Thirty patients scheduled for elective OPCABG were premedicated with intramuscular scopolamine 0.3 mg/kg and m...

Thyroid hormones (THs) are essential for fetal and post-natal nervous system development and also play an important role in the maintenance of adult brain function. Of the two major THs, T4 (3,5,3',5'-tetraiodo-l-thyronine) is classically viewed as an pro-hormone that must be converted to T3 (3,5,3'-tri-iodo-l-thyronine) via tissue-level deiodinases for biological activity. THs primarily mediat...

OBJECTIVE To characterize thyroid hormone levels at the time of diagnosis in the nosological types of thyrotoxicosis diagnosed in the population and to analyze determinants for serum thyroxine (T4) and tri-iodothyronine (T3). DESIGN Population-based study of thyrotoxicosis at disease onset. METHODS In the period 1997-2000, we prospectively identified all patients diagnosed with incident pri...

On the basis of our studies which demonstrated that T3 is a natural milk-borne component of cow mammary secretions, this study investigated the influence of T3 (and thyroxine, T4) on the serum Ig level (used here as an indicator of intestinal absorption). Forty healthy calves were given a single dose of either T3 or T4 with the first colostrum meal 6 h following birth. Blood samples were taken ...

OBJECTIVE Subclinical hypothyroidism (SCH) and its associations with atherosclerosis (AS) and cardiovascular disease remain controversial. The purpose of our study was to observe changes in endothelial functioning and hemodynamics in rats with SCH and to determine whether L-thyroxine (L-T4) administration affects these changes. METHODS In total, sixty male Wistar rats were randomly divided in...

Objective : The present study was designed to investigate variations in the levels of thyroid hormones (T3, T4) in breast and ovarian cancers patients. Methods : A total 120 subjects were recruited (without thyroid history) divided into three groups; A, B and C. Group A as control with healthy individuals. While group B and group C were consisting of breast cancer and ovarian cancer patient res...

Various methods are used to determine plasma thyroid hormones concentrations in medical diagnostic laboratories; but, some of them influence the results for thyroid hormone levels in domestic animals. The aim of this study was to compare the levels of two predominant plasma thyroid hormones using electrochemiluminescence immunoassay (ECLIA) and radioimmunoassay (RIA) methods in sheep. Blood sam...

samples was significantly higher than the level (41±2 ng per 100 ml) in 27 normal adult sera; the corresponding mean serum T4 of 12.7±0.8 ug per 100 ml in cord blood also was significantly higher than that (8.6±41.9 big per 100 ml) in 108 normal adults. By contrast, the mean serum T3 concentration in 15 cord blood samples, 24±3 ng per 100 ml, was significantly, lower than the value of 126±43.2 ...