INTRODUCTION Type 2 diabetes (T2D) candidate gene: potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) was suggested by conducting a genome wide association study (GWAS) in Japanese population. Association studies have been replicated among East Asian populations; however, the association between this gene and T2D in Southeast Asian populations still needs to be studied. This ...

The prevalence of type 2 diabetes (T2D) is increasing worldwide. Patients with T2D suffer from various diabetes-related complications. Since there are many patients with T2D that cannot be controlled by previously developed drugs, it has been necessary to develop new drugs, one of which is a glucagon-like peptide-1 (GLP-1) based therapy. GLP-1 has been shown to ameliorate diabetes-related condi...

OBJECTIVE To examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D. RESEARCH DESIGN AND METHODS The current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A gene...

OBJECTIVE To assess the independent causal effect of BMI and type 2 diabetes (T2D) on socioeconomic outcomes by applying two-sample Mendelian randomization (MR) analysis. RESEARCH DESIGN AND METHODS We performed univariable multivariable MR to jointly T2D outcomes. used overlapping genome-wide significant single nucleotide polymorphisms for as instrumental variables. Their impact household inco...

Context Little is known about the association between obesity and temporal trends in the incidence of diabetes in children and young adults. Objective We examined the recent incidence of types 1 and 2 diabetes in relation to a high body mass index (BMI) in UK children and young adults. Design Cohort and nested case-control. Setting A total of 375 general practices that contribute to the U...

BACKGROUND This study evaluated the measurement properties of a newly developed instrument - the Self-Management Profile for Type 2 Diabetes (SMP-T2D). METHODS The 18-item SMP-T2D assesses 12 constructs: level and perceived ease of performance in five self-care domains (blood glucose monitoring, medication-taking, healthy eating, being physically active, and coping), and two global constructs...

Background: This study was conducted to determine the effects of n-3 PUFAs supplementation on plasma homocysteine (Hcy) level, lipid profile and insulin resistance in patients with type 2 diabetes (T2D). Methods: This study is a double-blind controlled trial involving 70 patients with T2D selected from Yazd Diabetes Research Center in 2013. Patients were randomly assigned to receive either 2 g/...

Background: The potential role of exercise in physiological cardiac hypertrophy is rooted both hormonal and genetic components. Objectives: aim this study was to determine the impact resistance on expression PI3K AKT1 tissue type 2 diabetes (T2D) rats their hypertrophy. Methods: First, 21 male Wistar (220±20 g) were obese with 6-week high-fat diet (HFD) randomly assigned into non-diabetes, cont...

This study investigated the association of copper and zinc levels in the serum or urine of patients living in northeast China, with either prediabetes or diabetes. From January 2010 to October 2011, patients with type 1 diabetes (T1D, n = 25), type 2 diabetes (T2D, n = 137), impaired fasting glucose (IFG, n = 12) or impaired glucose tolerance (IGT, n = 15), and age/gender matched controls (n = ...

Fibroblast growth factors 19 and 21 (FGF19 and FGF21) have been implicated, independently, in type 2 diabetes (T2D) but it is not known if their circulating levels correlate with each other or whether the associated hepatic signaling mechanisms that play a role in glucose metabolism are dysregulated in diabetes. We used a cross-sectional, case/control, experimental design involving Class III ob...