Since Gowans first discovered the importance of lymphocytes in the immune response [1], a gradual understanding of their biology has evolved. Initially, B lymphocytes, the effector cells of humoral immunity, were studied in great detail. Largely because of the ability to obtain huge quantities of homogeneous antibodies-the B cell's primary product-through the study of multiple myeloma, tremendo...

The aim of this study was to evaluate the immune system and lymphocyte function in 41 Iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. The patients consisted of 20 splenectomized and 21 non-splenectomized patients. They were treated with Desferal, and had received repeated blood transfusion. Laboratory investigations included measurement of total T lymphocyt...

Human T and B lymphocytes differ morphologically and immunologically although little is known concerning their physiological parameters and biochemical constituents. In this study, microviscosity and lipid composition in normal human B and T lymphocytes were investigated. Microviscosity was examined using 1,6-diphenyl-1,3,5-hexatriene as a probe and lipid composition was analyzed by thin-layer ...

CD4+ regulatory (Treg) T cells play a central role in the immune system by potently controlling the responses of other immunocytes. Their activity appears to be essential not only for themaintenanceof immunological self-tolerancebut potentially also for the control of all physiological immune responses whether against normal self-proteins, microbes or cancerous cells. A fuller understanding of ...

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The common cold studies suggest implicitly that vitamin C intake affects the immune system. There are many experimental data indicating that vitamin C has effects on the immune system, but the experimental data have been inconsistent to a large extent (58-61). Although the role of vitamin C in the immune system still is not clear, there are certain effects that may be physiologically relevant. ...

Cancer stem cells (CSCs)/cancer-initiating cells (CICs) are characterized as a small population of cancer cells that have high tumor-initiating ability. CSCs/CICs are resistant to several cancer therapies, and eradication of CSCs/CICs is essential to cure cancer. How can we eradicate CSCs/CICs? Cytotoxic T lymphocytes (CTLs) might be a promising answer.

A sensitive procedure employing limiting dilution of activated lymphocytes and 51Cr release from highly labeled target cells was used to derive minimal estimates of the absolute frequency of cytotoxic T lymphocytes (CTL) present in a population of mouse lymphocytes activated to alloantigens of the major histocompatibility complex in bulk mixed lymphocyte cultures. From this figure (0.7-1.2%), t...

Neuraminidase treated T-lymphocytes from normals and CLL gave an enhanced response to PWM when compared to untreated T-lymphocytes. However the overall response of CLL T-lymphocytes was much lower as compared to normals. CLL T-lymphocytes showed an imbalance of T-subsets, where the Tu (Helper) were not only reduced 20.4± 2.96 but also diluted by increased ‘fy (Suppressor) 45 2+5 . 35, when comp...

Two subpopulations of human T lymphocytes expressing different antigen receptors, § / g and + / ˇ , emigrate into inflamed tissues in distinctive patterns. We compared the transmigration of § / g and + / ˇ T cells to C-C and C-X-C chemokines using an in vitro transendothelial chemotaxis assay. The C-C chemokines monocyte chemoattractant protein (MCP)-1, RANTES, macrophage inflammatory protein (...