It has long been known that thymus-derived lymphocytes (T cells) can produce cytokines that have powerful effects on hematopoiesis. All major classes of T cells--CD4 T helper cells, CD4 regulatory T cells, CD8 T cells, gammadelta T cells and NKT cells--produce a number of cytokines and chemokines that can modulate hematopoiesis. More recent research has shown that specific T helper cell types, ...

Peripheral T-lymphocytes subsets have been investigated in 36 patients with type I (insulin-dependent) diabetes of varying duration, 18 patients with type II (non-insulin-dependent) diabetes, and in 23 healthy subjects, using six different monoclonal antibodies. At the time of diagnosis of type I diabetes, there was evidence of an increase in cytotoxic T-lymphocytes, a decrease in suppressor T-...

Objective. To study the effect of local photodynamic therapy (PDT) on immunity in patients with maxillofacial region and neck phlegmonas. Materials methods. The included 62 phlegmon neck. Two groups were formed. Patients 1st group treated locally according to traditional second additionally underwent PDT background complex therapeutic measures. Results. Under influence preparation «Fotolon» phl...

To better understand the lung and systemic responses of helper T cells mediating memory immunity to Mycobacterium tuberculosis, we used three- and four-color flow cytometry to study the surface phenotype of CD4(+) lymphocytes. Bronchoalveolar lavage (BAL) fluid and peripheral blood (PB) samples were obtained from a total of 25 subjects, including 10 tuberculosis (TB)-infected subjects, 8 purifi...

Lymphocyte is one of the subtypes of white blood cell (WBC) in immune system. Lymphocytes contain T cells, natural killer cells , and B cells. They are the head type of cell found in lymph, which for this reason the name "lymphocyte". Lymphocytes can be recognized by their large nucleus. Infiltration of immune cells in the central nervous system (CNS) helps the start of chronic pain. ...

Viruses such as lactate dehydrogenase-elevating virus and adenovirus induce in vivo a polyclonal activation of murine B lymphocytes, followed by a marked increase in the production of immunoglobulin G2a (IgG2a). The role of T lymphocytes in this phenomenon was studied by injection of an anti-CD4 monoclonal antibody able to inhibit the T-helper function. This treatment profoundly depressed the p...

We examined the specificity of the recently reported alterations in circulating lymphocytes in heatstroke by determining lymphocyte subsets in 14 consecutive heatstroke patients before and after cooling and in 7 heat-stressed controls using single- or two-color immunofluorescence flow cytometry. The relationship with catecholamine levels was also studied. In heatstroke, percentages of T (CD3(+)...

Leprosy is a chronic infectious disease whose evolution involves complex immune mechanisms of the host that influence the clinical presentation of the disease. For many years, the main interpretation of the host defense response was based on characterization of the established immune paradigm between T helper (Th) 1 and Th2 lymphocytes. However, with advances in the knowledge of immunology, new...

Peripheral blood lymphocytes from 14 patients with idiopathic aplastic anemia were examined to determine their capacity to differentiate into immunoglobulin (lg) producing cells in the presence of pokeweed mitogen (PWM). Four patients had hypogammaglobulinemia. Lymphocytes from ten patients without and one with hypogammaglobulinemia were capable of differentiating into lg-producing cells. Lymph...

The Reed-Sternberg cell/lymphocyte rosette characteristic of Hodgkin's disease tissue and cell suspensions was investigated with monoclonal antibodies on fresh viable cell suspensions prepared from nine cases of Hodgkin's disease. The biopsy material comprised six spleens and three lymph nodes. The majority of the rosetting lymphocytes were T cells, primarily of the helper subset. Some of the a...