Pharmacist Male 54 80 mg and 120 mg at bedtime 29 d (1st trial); “within hours” (2nd trial) Yes Yes aRange, 20–69 years (n = 5); median = 33 years (n = 5). bRange, 40–200 mg/d; median = 80 mg/d. cRange, 11–29 days; median = 14 days. Abbreviations: DRESS = drug reaction with eosinophilia and systemic symptoms, NA = not applicable. US Food and Drug Administration Warning About the Risk of Drug Re...

Metamizole, a non-steroidal anti-inflammatory drug with weak anti-inflammatory and spasmolytic effects, is used as an analgesic and antipyretic agent. Many adverse reactions to metamizole, such as early or late-onset systemic reactions and bone marrow suppression, have been identified. In this report, we present a case of systemic reaction after the application of parenteral metamizole (Novalgi...

conclusions systemic arterial leukocyte filtration reduces the intubation time but has no other beneficial effect on the outcome of patients undergoing cabg or valve surgery. results the postoperative intubation time was significantly shorter in patients with leukocyte filters (0.014). there was no significant difference between two groups regarding other outcome relatedvariables. patients and ...

The present study shows that systemic dopamine receptor blockade impaired movement initiation of rats, trained in a simple reaction time task for rapid initiation of locomotion in response to a combined optic/acoustic cue. Reaction time, movement time and the accelerative force were recorded for each initiation of locomotion. Results indicate a dose-related increase of reaction time following s...

Local anesthetic systemic toxicity (LAST) is a rare yet devastating complication from the administration of local anesthesia. The ability to recognize and treat LAST is critical for clinicians who administer these drugs. The authors reviewed the literature on the mechanism, treatment, and prevention of LAST, with the goal of proposing a practical method for its management.

W e present a case of a systemic allergic red tattoo reaction that required excision and skin grafting after failure of other therapies. Tattoos are associated with an increased risk of infection , eczema, psoriasis, hyperplasia, granulomatous reactions, and neoplasm, with red ink as the most common culprit for allergic reactions. Although artists have replaced dangerous mercury-based cinnabar ...

Acute pancreatitis (AP) is a common disease, which usually exists in its mild form. However, in a fifth of cases, the disease is severe, with local pancreatic complications or systemic organ dysfunction or both. Because the development of organ failure is the major cause of death in AP, early identification of patients likely to develop organ failure is important. AP is initiated by intracellul...