background: leishmaniasis is a complex disease which presents as visceral, cutaneous and mucocutaneous forms. the current treatment options for this infection are very limited and the immunological state of the host appears to play an important role in the efficacy of the treatment. immunostimulation through immune response activating agents such as imiquimod is another rational approach for th...

background: to evaluate immunotherapy against canine visceral leishmaniasis, leishmania ma­jor antigen and heat-killed mycobacterium vaccae (srl172) were used as stimulators of immune de­fense mechanisms and the results were compared with standard chemotherapy meglumine antimoni­ate. methods: nineteen mongrel dogs aging 1-3 years old were used in this experiment. infection was carried out in 15...

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Abstract Background Glucantime is the first line agent for treatment of cutaneous leishmaniasis (CL). It has adverse effects on blood elements. This research has been done to evaluate the blood complications of this medicine in patients with cutaneous leishmaniasis. Methods This clinical trial was done at Nikpour clinic, Yazd, Iran. Blood samples were collected from patients diagnosed with ...

Background and aim: Cutaneous leishmaniasis is an endemic disease in Iran. Although there are many different treatments for this disease, there is not any effective treatment yet. Since there has been a number of different reports on the effectiveness of Cassia fistula plant in the treatment of leishmaniasis, the efficacy of concentrated boiled extract and hydro alcoholic extract of Cassi...

pentavalent antimonials are still the first drug of choice for the treatment of cutaneous leishmaniasis (cl). like other treatments, they can cause adverse reactions including musculoskeletal pain , gastrointestinal disturbances, and mild to moderate headaches. in this paper, we report the first case of an infant who developed acute urticaria after her mother’s parenteral use of meglumine antim...

Various chemical drugs have been used for leishmaniasis treatment, but their side effects and drug resistance have led to look for new effective compounds. Crataegus microphylla the traditional and medicinal herb is a valuable source of new Pharmaceutical agents. The extract were prepared The extract obtained by maceration method, and diluted with 5% DMSO. Leishmania major promastigotes were cu...

Cutaneous leishmaniasis (CL) can be seen in 2 forms, zoonotic and anthroponotic, in Iran. In this study, epidemiological aspects of CL were studied during an 8-year period (2009-2016) in city of Kashan, central Iran. The demographic and epidemiological data, including age, sex, occupation, number and site of the lesions, treatment regimen, past history of CL, and season of all patients were gat...