BACKGROUND The efficacy of a new pharmacologic agent for asthma, in this instance the leukotriene receptor antagonist montelukast, is determined in controlled trials in research subjects. The utility of a new drug is determined by multiple uncontrollable factors in individual patients. OBJECTIVE To assess the utility of montelukast in the management of persistent asthma. DESIGN Observationa...

discussion early recognition of dress syndrome is of a particular importance. although rare, in newborn infants with the presence of skin rash, liver involvement, hyper-eosinophilia and lymphadenopathy, dress diagnosis should be highly suspected and prompt intervention including withdrawal of causative drug is required to prevent potentially fatal outcomes. introduction drug rash with eosinophi...

Inhaled corticosteroids are widely accepted in the treatment of cystic fibrosis. Long-term use may cause systemic complications, especially high-dose fluticasone. We report about a young man who presented with encephalopathy after excessive physical activity caused by secondary adrenal insufficiency. He recovered quickly after systemic corticosteroid replacement therapy. This problem is conside...

Introduction Hippocampal atrophy is associated with corticosteroid use and may be related to cognitive impairment in systemic lupus erythematosus (SLE). Some biomarkers associated with neuronal injury have been associated with neuropsychiatric SLE, but their roles in the pathogenesis and its validity and clinical applicability has not been studied in childhood-onset systemic lupus erythematosus...

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a delayed drug reaction defined by physical signs and laboratory parameters. Mini-DRESS is a new entity, in cases that display some but not all features of DRESS. Cases of mini-DRESS have a less protracted course, and respond well to systemic corticosteroid treatment.

Sarcoidosis is a systemic disease mainly affecting the mediastinum and lungs. The other manifestations are much rarer lead to diagnostic therapeutic wanderings. present study reports case of lymph node sarcoidosis revealed by long-lasting fever. diagnosis based on clinical paraclinical arguments elimination causes lymphadenopathy. evolution favorable after 6 months corticosteroid therapy.

Corticosteroids are routinely injected into soft tissues, tendon sheaths, bursae, and joints. These anti-inflammatory agents have different potency and solubility, and solubility is inversely correlated with the duration of action. Corticosteroids carry a low risk of complications but commonly cause systemic and local adverse effects. The use of intra-articular corticosteroid injections in the ...

this case report demonstrates fatal gastrointestinal vasculitis as a rare presentation of systemic lupus erythematosus. a 34-year-old woman presented with abdominal pain and diarrhea. anti nuclear antibody was positive and high titre of anti-ds dna antibody was also reported. treatment with corticosteroid and supportive cares were started; however, her condition worsened. eventually, she was co...

BACKGROUND Recent international guidelines recommend intra-articular corticosteroid injections for patients with hip osteoarthritis who have moderate to severe pain and do not respond satisfactorily to oral analgesic/anti-inflammatory agents. Of the five available randomized controlled trials, four showed positive effects with respect to pain reduction. However, intra-articular injection in the...

Fluticasone propionate is a locally acting potent corticosteroid and is registered in the Netherlands since November 1990. It is marketed as nasal drops and nasal spray (Flixonase) for the indications vasomotor and allergic rhinitis, nasal polyps, and as inhalation corticosteroid (ICS) (Flixotide) in both an inhalation dosisaerosol and a powder inhalation form for indications asthma and chronic...