The aim of the work was to study pathogenicity newly emerging variants SARS-CoV-2 on model Syrian golden hamster. Materials and methods . We used strains virus related VOC circulating in territory Russian Federation. experiments were carried out outbreed hamsters obtained from nursery SSC VB “Vector”. infectious titer coronavirus tissue samples collected infected laboratory animals determined a...

In the course of analysis of ENU-induced mutations in Syrian hamsters, a novel dominant anophthalmic white mutant (Wh(V203)) with hearing loss was recovered. Because of this phenotype and a close linkage to the Tpi gene, the Mitf gene was considered as a candidate gene. In the Mitf cDNA, a deletion of 76 bp covering the entire exon 7 was detected. Further molecular analysis revealed a T --> A e...

This study investigates possible alterations in exons 5 through 8 of the p53 gene and altered p53 protein expression in the Syrian golden hamster model of pancreatic ductal adenocarcinoma. In the Syrian hamster p5.3 sequence, 1469 base pairs are presented for the genomic regions surround ing exons 5 through 8, along with the primer sequences specific for the enzymatic amplification of the indiv...

The Syrian hamster embryo (SHE) cell transformation assay is widely used to screen chemicals for carcinogenic potential. However, the biochemical mechanisms of transformation in SHE cells are incompletely understood relative to other rodent systems. Thus identification of proteins which change during transformation can provide clues to biochemical mechanisms. Previously, we published a map of S...