Vitamin D3 and metformin are widely used in humans for regulating mineral metabolism and as an antidiabetic drug, respectively; and both of them have been shown to have chemopreventive effects against various tumors. This study was designed to investigate the potential synergistic chemopreventive effects of vitamin D3 and metformin against the development of early colon neoplasia in two models....

This study aimed to assess the antibacterial and antibiotic potentiating property of Vangueria madagascariensis (VM) (fruit and leaf extracts) against 10 clinical isolates. A microdilution broth susceptibility assay for bacteria was used for the determination of the minimum inhibitory concentration (MIC) and associated with antibiotics to evaluate any synergistic effect. VM extracts were found ...

The aim of the present study was to investigate the influence and the mechanisms of cineole and terpineol on the in-vitro transdermal delivery of huperzine A from microemulsions, and their potential synergistic effect on the permeation enhancement. The transdermal delivery of huperzine A from microemulsions with different concentrations of cineole and terpineol through the rat abdominal skin wa...

The initiation of sound change requires the emergence of innovated variants. One possible source of innovated variants is non-faithful transference of linguistic features during accommodation to a received speech signal. If the subphonemic cues associated with a phonological contrast are realized differently in an accommodating speaker's speech than in both the speaker's previous speech and in ...

antibiotic resistance is an important problem in antibiotic treatment of infections, particularly in hospitals. tomatidine is a plant secondary metabolite with antimicrobial and antifungal effects. this study examined the possible synergistic effect tomatidine with several antibiotics against standard and clinical strains of staphylococcus aureus, enterococcus faecalis, pseudomonas aeruginosa a...

Ruthenium Nanoparticles In article number 2206806 by Alexis Bordet, Walter Leitner, and co-workers, the aqueous phase hydrogenation of CO2 to formate using Ru nanoparticles immobilized on supported ionic liquid phases ([email protected]) is reported. A synergistic enhancement catalyst activity productivity observed for sulfonic acid-functionalized [email protected](SO3H-X) materials, rationaliz...

In vitro growth of Plasmodium falciparum is restricted in glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes (RBC), as a result of oxidative stress. Bathocuproine disulphonate (BCS), a copper chelator, as well as cysteine have been shown to synergistically stimulate the in vitro growth of various mammalian cells and Trypanosoma under oxygenated conditions. We examined the effects o...

The tomato cv. Fukuju n. 2 was used for studying the effect of single and double infections with Potato virus X (PVX) and Tobacco mosaic virus (TMV). Mixed infection resulted in a synergistic increase of disease severity, where more growth reduction was seen with simultaneous inoculations than with sequential inoculations at four-day intervals. At five and 12 days postinoculation, the increased...

C-reactive protein (CRP) and oxidized LDL (ox-LDL) are associated with inflammatory lesions, such as coronary artery disease, in which monocytes and matrix metalloproteinases (MMPs) may play a major role in the rupture of atherosclerotic plaques. Monocytes are recruited to inflammation sites by monocyte chemoattractant protein-1 (MCP-1), which may also participate in the activation of monocytes...