The synergism of passive smoking and artificial feeding on hospitalization for respiratory illness in early childhood was examined among 2,227 subjects born in the last quarter of 1983 in Chang-Ning District, Shanghai, People's Republic of China. The eligible families were visited by the trained interviewers. A loglinear model shows no interaction on a multiplicative scale between these two fac...

LYl7l555. SinLe forskolin activates adenylyl cyclase, effects of Dr receptors on Na'/X+-ATPase would then be mediated via protein phosphorylation and CAMP-dependent protein kinase. There are reports that Na+/K+-ATPase may be regulated by phosphoryl-ation, and CAMP has been reported to inhibit the enzyme via a cAMP-&pendent protein kinase7, consistent with the scheme outlined above. However, it ...

The ability of small numbers of LN cells to produce cytotoxic lymphocytes on in vitro culture with allogeneic stimulator cells is greatly augmented by the addition of spleen cells from athymic nude mice. The possibility that the synergism is a result of improved culture conditions or a "feeder effect" is excluded. All cytotoxic cells found in these cultures are shown to be T cells and to arise ...

Viral lung infections increase susceptibility to subsequent bacterial infection. We questioned whether local lung administration of recombinant adenoviral vectors in the sheep would alter the susceptibility of the lung to subsequent challenge with bacterial lipopolysaccharide (LPS). We further questioned whether local lung expression of elafin, a locally produced alarm anti-LPS/anti-bacterial m...

The purpose of this study was to determine the effects of the vasoactive perivascular neuropeptide substance P (SP) on the growth and function of vascular endothelial cells in serum-free culture conditions with cells quiescent in the G0-G1 phase of the cell cycle and to characterize the response. In addition, interactions between SP and other growth factors and neuropeptides including insulin, ...

Antibiotic combinations are used to enhance antibacterial efficacy and to prevent the development of resistance. We have tested a possible synergistic effect of several antibacterial combinations on Bacillus anthracis. The in vitro activities of antibiotic combinations against two strains of B. anthracis, strain Sterne and the Russian anthrax vaccine strain STi, were tested by the fractional in...

For a long time it was believed that 2-adrenergic receptor agonists used in the treatment of obstructive airway diseases worked primarily on airway smooth muscle cells, causing relaxation, whereas glucocorticoids primarily improved airway function via their anti-inflammatory action, indicating that their clinical synergism occurred at the organism rather than the cellular level. However, it is ...

Pancreatic cancer (PaCa) is a major health concern due to its aggressiveness and early metastasis. Current treatments for PaCa are limited by development of resistance against therapy. As an alternative strategy, we assessed the combinatorial effect of dietary compounds, garcinol and curcumin, on human PaCa cells (BxPC-3 and Panc-1). A significant (P < 0.05) dose-dependent reduction in cell via...

When primary domestic sewage sludge was combined with settled sewage or secondary-treatment plant effluent, synergism resulted. The activity (measured by oxygen uptake, and the removal of Kjeldahl nitrogen and orthophosphate from solution) which resulted from incubating sludge together with settled sewage exceeded the sum of the activities when these components were incubated separately. A simi...