This review will address the management of hyponatremia caused by the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in hospitalized patients. To do so requires an understanding of the pathogenesis and diagnosis of SIADH, as well as currently available treatment options. The review will be structured as responses to a series of questions, followed by a presentation of an algor...

BACKGROUND It is unknown whether the appropriate use of percutaneous coronary intervention (PCI) has improved over time and whether trends in PCI appropriateness have been accompanied by changes in the use of PCI. METHODS AND RESULTS We applied appropriate use criteria to determine the appropriateness of all 51 872 PCI performed in Washington State from 2010 through 2013. We evaluated the num...

BACKGROUND Acute fever is the most common pediatric condition encountered in general practice and a source of parental concern that can result in inappropriate behavior. The main objective of this study was to describe and quantify parental reassurance concerning their feverish child in the context of visits to rural general practitioners (GPs). METHOD The study included the parents of 202 fe...

Amae is a Japanese term that refers to an individual‟s inappropriate behavior when he/she presumes indulgence from a significant other. The link between attachment style and amae has been debated, but few studies have examined this link empirically. This study examined the association of attachment style with amae behavior in Japanese dating couples over a two-week period. Results showed that f...

Switching tasks prolongs response times, an effect reduced but not eliminated by active preparation. To explore the role of attentional selection of the relevant stimulus attribute in these task-switch costs, we measured eye fixations in participants cued to identify either a face or a letter displayed on its forehead. With only 200 ms between cue and stimulus onsets, the eyes fixated the curre...

For the majority of Belgian hospitals, a pharmacist-led full medication review process is not standard care and, therefore, challenging to introduce. With this study, we aimed to evaluate the successes and barriers of the implementation of a pharmacist-led full medication review process in the geriatric ward at a local Belgian hospital. To this end, we carried out an interventional study, perfo...

The fortuitous detection of SIADH is described in a patient receiving clomipramine therapy.

Inappropriate polypharmacy, especially in older people, imposes a substantial burden of adverse drug events, ill health, disability, hospitalization, and even death. The single most important predictor of inappropriate prescribing and risk of adverse drug events in older patients is the number of prescribed drugs. Deprescribing is the process of tapering or stopping drugs, aimed at minimizing p...