In this study, we tested the hypothesis that reducing shear rates in postcapillary venules causes CD18-dependent, selectin-independent leukocyte rolling. Intravital microscopy was used to assess shear rate-dependent leukocyte rolling in 25- to 40-microns rat mesenteric venules. Pretreatment of animals with 25 mg/kg fucoidin, a carbohydrate moiety that binds to and inhibits selectin function, es...

In order to achieve the nonsmooth surface drag reduction structure on the inner polymer coating of oil and gas pipelines and improve the efficiency of pipeline transport, a structural model of the machining robot on the pipe inner coating is established. Based on machining robot, an experimental technique is applied to research embossing and coating problems of rolling-head, and then the moldin...

In this paper x, r are real numbers. Let A be a set. We say that A is symmetrical if and only if: (Def. 1) For every complex number x such that x ∈ A holds −x ∈ A. Let us note that there exists a subset of C which is symmetrical. Let us observe that there exists a subset of R which is symmetrical. In the sequel A denotes a symmetrical subset of C. Let R be a binary relation. We say that R has s...

We calculate the friction force acting on a hard cylinder or spherical ball rolling on a flat surface of a viscoelastic solid. The rolling-friction coefficient depends non-linearly on the normal load and the rolling velocity. For a cylinder rolling on a viscoelastic solid characterized by a single relaxation time Hunter has obtained an exact result for the rolling friction, and our result is in...

Strip tearing during cold rolling process has always been considered among the main concerns for steel companies, while several works have been done so far regarding the examination of this issue. In this paper, experimental data from cold rolling tandem mill is used for detecting strip tearing. Sensors are placed across the cold rolling tandem mill, to collect information on parameters (such a...

for helpful discussions and comments, and to Pam Dillon and Paula Drew for assistance in preparing this document. The views expressed are those of the authors and should not be attributed to the Reserve Bank of Australia.

Selectin-mediated cell adhesion is an essential component of the inflammatory response. In an attempt to unambiguously identify molecular features of ligands that are necessary to support rolling adhesion on P-selectin, we have used a reconstituted ("cell-free") system in which ligand-coated beads are perfused over soluble P-selectin surfaces. We find that beads coated with the saccharides sial...

Leukocyte recruitment into inflammatory sites is initiated by a reversible transient adhesive contact with the endothelium called leukocyte rolling, which is thought to be mediated by the selectin family of adhesion molecules. Selectin-mediated rolling precedes inflammatory cell emigration, which is significantly impaired in both P- and L-selectin gene-deficient mice. We report here that approx...

Leukocyte rolling has been postulated to be mandatory for subsequent leukocyte adhesion and tissue injury observed during ischemia/reperfusion. The objective of this study was to systematically assess this hypothesis at the microvascular level by examining the effects of various concentrations of a selectin-binding carbohydrate (fucoidin) on the increased rolling and adhesion of leukocytes in p...

The mechanical rolling conditions in hot strip mills are precisely defined by various variables, which are taken directly froth the rolling schedule (separation force, torque. speed. strip thickness) or calculated from figures of the rolling schedule and dimensions of the mill (strip reduction, roll diameter etc.). These variables allow to describe the mechanical rolling conditions of all passe...