In this commentary, Qun Zheng and Michael L. Nonet examine Edwards et al.’s article in which they provide evidence for a domain in invertebrate neurons similar to the vertebrate axonal initial segment that serves to restrict certain organelles from entering the axonal compartment. In their article published in this month’s GENETICS, Edwards et al. (2013) implicate the UNC-16/JIP3/SYD as a criti...

Abbreviations: CAI – Codon Adaptation Index; D – effective gene family size (number of additional gene duplicates); E-value – expectation value; KD – knockdown; KO – knockout; MIPS Munich Information Center for Protein Sequences; P(S) – probability of survival upon singleor double-gene KO or KD; R – squared Pearson correlation coefficient; SGA– Synthetic Genetic Array; SSL – synthetic sick or l...

We report on the electromagnetic response of digital ferromagnetic heterostructures sDFHd: systems with d-doped MnAs layers separated by GaAs spacers of variable thickness syd. The gross features of the infrared conductivity of DFH samples are consistent with the notion that these digital structures are GaAs/Ga1−xMnxAs superlattices. This conclusion is supported by a combination of spectral wei...

BACKGROUND The underlying basis for the seasonality of influenza A viruses is still uncertain. Phylogenetic studies investigated this phenomenon but have lacked sequences from more subtropical and tropical regions, particularly from Southeast Asia. METHODOLOGY/PRINCIPAL FINDINGS 281 complete hemagglutinin (HA) and neuraminidase (NA) sequences were obtained from influenza A(H3N2) viruses, coll...

How organisms control organ size is not fully understood. We found that Syd/JIP3 required for proper wing in Drosophila. JIP3 mutations are associated with defects mammals. The underlying mechanisms well discovered inhibition results a downregulation of the inhibitor apoptosis protein 1 (Diap1) Drosophila wing. Correspondingly, deficient tissues exhibit ectopic cell death and yield smaller wing...