To determine if oral dosing with the CFTR-potentiator ivacaftor (VX-770, Kalydeco) improves CFTR-dependent sweating in CF subjects carrying G551D or R117H-5T mutations, we optically measured sweat secretion from 32-143 individually identified glands in each of 8 CF subjects; 6 F508del/G551D, one G551D/R117H-5T, and one I507del/R117H-5T. Two subjects were tested only (-) ivacaftor, 3 only (+) iv...

UNLABELLED Heat acclimation (HA) reportedly conveys conservation in sweat micromineral concentrations when sampled from arm sweat, but time course is unknown. The observation that comprehensive cleaning of the skin surface negates sweat micromineral reductions during prolonged sweating raises the question of whether the reported HA effect is real or artifact of surface contamination. PURPOSE ...

Effects of sweat gland training by daily local heating were examined and its significance in heat acclimatization was evaluated. Training by 2-hr immersion of an arm in hot water of 43 degrees C caused distinct augmentation of sweat gland activity in the trained area, with reduction in the degree of hidromeiosis, when tested by an arm bag collection of sweat. Concentrations of sweat electrolyte...

Apocrine glands are the major type of sweat gland in dogs, and distribution of eccrine sweat glands is limited to footpad (Goldschmidt and Shofer, 1992). Apocrine sweat gland tumors are rather common in dogs and tend to occur on the head, neck and limbs. The Golden Retriever is a breed that shows a predisposition to such tumors (Kalaher et al., 1990). The tumor was greatly resembles its human c...

It was generally believed that Cystic fibrosis (CF) is rare among Arabs; however, the few studies available from Egypt and other Arabic countries suggested the presence of many undiagnosed patients. The aim of the present study was to determine the frequency of CF patients out of the referred cases in a single referral hospital in Egypt. A total of 100 patients clinically suspected of having CF...

Q-Sweat, a commercial quantitative sweat measurement system, is modeled on quantitative sudomotor axon reflex testing (QSART). This study investigated the sweat response using Q-Sweat and Mayo-QSART recordings under identical conditions in healthy normal controls. Ninety-four participants were recruited for this study. All participants underwent randomized bilateral QSART recordings over the fo...

BACKGROUND Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS Intracutaneous skin tests with autologous sweat were performed on 50 AD patients and 24 control subjects. In skin biopsies, tryptase and ...

This paper presents the fabrication and the performance of a novel, wearable, robust, flexible and disposable microfluidic device which incorporates micro-Light Emitting Diodes (μ-LEDs) as a detection system, for monitoring in real time mode the pH of the sweat generated during an exercise period. Up to now sweat analysis has been carried out using awkward methods of collecting sweat followed b...

Much emphasis has been placed on the measurement of physical parameters at the body support interface in order to detect and moderate conditions which could result in pressure damage to soft tissues. Major difficulties are encountered both in the design of instrumentation and interpretation of the data collected. Metabolic processes in sweat glands that control sweat secretion have been shown t...

Because sweat secretion is facilitated by mechanical contraction of sweat gland structures, understanding their structure-function relationship could lead to more effective treatments for patients with sweat gland disorders such as heat stroke. Conventional histological studies have shown that sweat glands are three-dimensionally coiled tubular structures consisting of ducts and secretory porti...