BACKGROUND X-linked hypohidrotic ectodermal dysplasia (XLHED), the most common type of ectodermal dysplasia, is caused by EDA gene mutations. Reduced sweating contributes substantially to XLHED associated morbidity and mortality. To characterise the genotype-phenotype relationship, sweat gland function was assessed non-invasively in XLHED patients and healthy controls. SUBJECTS AND METHODS In...

Eccrine Porocarcinoma (ECP) is a malignant tumour arising from the intraepithelial ductal parts of the sweat gland. It has also been described as malignant hidroacanthoma simplex, sweat gland carcinoma, malignant intra-epidermal eccrine poroma, eccrine poroepithelioma, dysplastic poroma, malignant syringo acanthoma and porocarcinoma. Treatment with wide local excision but metastatic lesions can...

In order to determine whether the precursor solution of sweat is abnormal in cystic fibrosis, osmolality and concentrations of sodium and chloride were measured in fluid obtained by micropuncture from the sweat gland coil of the nail fold of patients with this disease. Osmolality was 323+/-4.8 SE (mOsm/kg of water), sodium concentration was 151+/-1.1 SE (mEq/liter), and chloride concentration w...

The transforming growth factor-beta superfamily is thought to be involved in the regulation and control of growth and differentiation. These growth factors signal through transmembrane serine/threonine kinase receptors. The activation of type I receptor kinase phosphorylates a family of intracellular signalling proteins called Smads. In the present study, we wanted to localize type I and type I...

Nodular hidradenoma is a rare benign tumour of eccrine sweat gland. It usually presents as a solitary, intradermal nodule 0.5 -2 cms in diameter in most instances. It may be red, brown or bluish and sometimes may show superficial ulceration. We are presenting a case report of 50 years old female who presented with painless swelling measuring 3×3 cms over right leg for 2 years. Excisional biopsy...

Myoepithelial cells are smooth muscle like cells having epithelial origin. They are present in salivary glands, mammary gland, sweat gland and lacrimal gland. Myoepithelial cells are stellate or spindle shaped with 4 to 8 cytoplasmic processes. They play vital role during expulsion of saliva and regulates the electrolytic exchange. They also act as tumor suppressor and are considered very impor...