s | 23 investigate the efficacy of ETX treatment on absence seizures and its effect on potentially observable cardiovascular changes in genetic absence epileptic WAG/Rij rats. Method: We divided 2-month-old Wistar and WAG/Rij rats into two groups (n=16): Control and ETX groups. The ETX groups were treated with ETX (orally, 300 mg/kg/day) for 3 months. Control groups received physiological salin...

Human and experimental studies indicate that molecular genetic changes in GABA(A) receptors may underlie the expression of spike-and-waves discharges (SWDs) occurring during absence seizures. However, the full spectrum of the genetic defects underlying these seizures has only been partially elucidated, the expression and functional profiles of putative abnormal protein(s) within the thalamocort...

PURPOSE In Genetic Absence Epilepsy Rats from Strasbourg (GAERS), age-related absence seizures start to appear from postnatal day (PN) 30 concomitant with 'spike and wave discharges' (SWDs) appearing on cortical EEG recordings. The aim of this study was to investigate the effect of early chronic levetiracetam (LEV) treatment on the development of SWDs in young and adult GAERS. METHODS From PN...

Recessive mutations in genes encoding voltage-gated Ca2+ channel subunits alter high-voltage-activated (HVA) calcium currents, impair neurotransmitter release, and stimulate thalamic low-voltage-activated (LVA) currents that contribute to a cortical spike-wave epilepsy phenotype in mice. We now report thalamic LVA current elevations in a non-Ca2+ channel mutant. EEG analysis of Coloboma (Cm/+),...

Thermo-gelling injectable nanogels, with no burst release of loaded drug, were prepared by a simple route by combining self assembled nanocapsules of amphiphilically modified chitosan with glycerophosphate di-sodium salt and glycerol. The potential as a depot drug delivery system was demonstrated in vivo through the therapeutic effect of ethosuximide (ESM) loaded nanogels, suppressing spike wav...

Current keyword-based Web search engines (e.g. Googlea) provide access to thousands of people for billions of indexed Web pages. Although the amount of irrelevant results returned due to polysemy (one word with several meanings) and synonymy (several words with one meaning) linguistic phenomena tends to be reduced (e.g. by narrowing the search using human-directed topic hierarchies as in Yahoob...

The past year has seen a dramatic increase in the amount of social information published in RDF documents. Our investigations [1, 2] show that the Friend of a Friend (FOAF) ontology [3] is among the most used semantic web ontologies. This is true if we measure the number of semantic web documents (SWDs) that use the FOAF namespace, as Table I shows, or the number of triples using FOAF terms. Th...

Drosophila suzukii, known as the spotted wing drosophila (SWD), is a major pest of berries and stone fruits. In 2014 it was recorded for first time in Nordic countries. this study, we report observations D. suzukii Finland. The trap catches SWD were observed 2019 North Savo at berry farm that handles imported berries. 2020–2021, no adult flies trapped or near farm, but August 2022, SWDs caught ...