Phasins or PhaPs are a group of amphiphilic proteins that are found attached to the surface of microbial polyhydroxyalkanoate (PHA) granules. They have both structural and regulatory functions and can affect intracellular PHA accumulation and mediate protein folding. The molecular basis for the diverse functions of the PhaPs has not been fully understood due to the lack of the structural knowle...

Surfactant-enhanced hollow fiber liquid phase (SE-HF-LPME) microextraction was applied for the extraction of melamine in conjunction with high performance liquid chromatography with UV detection (HPLC-UV). Sodium dodecyl sulfate (SDS) was added firstly to the sample solution at pH 1.9 to form hydrophobic ion-pair with protonated melamine. Then the protonated melamine-dodecyl sulfate ion-pair (M...

Abstract Background The main objective of the present study was to formulate, optimize and characterize solid lipid nanoparticles (SLNs) loaded with Atorvastatin Calcium (ATS) Vinpocetine (VIN) as a potential drug delivery system improve its solubility assess anti-tumor activity on cell lines. SLNs were formulated by emulsification high speed homogenization followed probe sonication. Central co...

Vortex-assisted liquid-liquid microextraction (VALLME) coupled with high-performance liquid chromatography (HPLC) is proposed here for the rapid determination of octanol-water partitioning coefficients (Kow). VALLME uses vortex agitation, a mild emulsification procedure, to disperse microvolumes of octanol in the aqueous phase thus increasing the interfacial contact area and ensuring faster par...

poly-(alkylcyanoacrylate) ester particles have been used for the preparation of different formulations ranging from ophthalmic delivery systems to cancer chemotherapy carriers in clinic. the aim of this study was to prepare and characterize poly-(methyl ethyl cyanoacrylate) (pmeca) particles containing 5-aminosalicylic acid (5-asa). pmeca particles were prepared using the inverse emulsification...

Fragrances are amphiphilic and highly volatile, all of which makes them a challenging cargo to efficiently encapsulate and retain in microcapsules using traditional approaches. We address these limitations by introducing a new strategy that combines bulk and microfluidic emulsification: a stable fragrance-in-water (F/W) emulsion that is primarily prepared from bulk emulsification is incorporate...

In this paper, the effects of several factors such as surfactant concentration, solute concentration, impeller speed and holdup on the mean drop diameter ( ) during emulsification have been studied in a single-stage mixer-settler extractor. A video technique has been developed in order to measure drop size distribution in the mixing chamber using a digital camera. The results show decreases wi...

Systematic set of emulsification experiments is performed to elucidate the role of several factors, which control the process of drop breakup during emulsification in turbulent flow. As starting oil-water premixes we use emulsions containing monodisperse oil drops, which are generated by the method of membrane emulsification. By passing these premixes through a narrow-gap homogenizer working in...

In this study, an optimized nanodispersible oral dosage form (containing a lactate ester) was developed for cilostazol (CZL). CZL is a phosphodiesterase inhibitor used for intermittent claudication. We aimed to improve the dissolution rate and absorption of CZL giving it a better chance of oral bioavailability, and to evaluate its stability on storage. Suitable compositions of nanoemulsion prec...

A study on the extraction of Acetaminophen (ACTP) which is also known as paracetamol, from aqueous solution by emulsion liquid membrane process using Taylor-Couette Column (TCC) was investigated. An ELM consists of three phase system which are the external, membrane and internal phases. The external phase containing the ACTP aqueous solution to be treated. Basically, the internal and membrane p...