The biologically active mediators of antigen-specific T suppressor cells can combine with antigen on cells that are specialized to present antigen (APC) and render these APC incapable of presenting not only the specific antigen that the product of the T suppressor cell sees but also any other antigen in or on the APC. Thus, antigen-bearing suppressed APC fail to activate either the helper or su...

NONOMURA, A., TANINO, M., KURUMAYA, H., OHTA, G., KATO, Y. and KoBAYASHI, K. Studies of Immune Functions of Patients with Chronic Hepatitis. Tohoku J. exp. Med., 1982, 137 (2), 163-177 Peripheral T cells from patients with chronic active hepatitis (CAH) showed a significantly decreased suppressor effect (or increased helperr effect) on allogeneic B cell differentiation into Ig-producing cells (...

T-suppressor-cell activity was analyzed by use of an intermediate culture system that allows the study of T-cell interactions in the absence of concomitant inducer effects on B cells. Activated suppressor T cells were incubated with their potential target cells [immune Ly-1+,Ly-2- (Ly-1) cells] for 24-48 hr, and then the Ly-1 cells were reisolated by removing the suppressor cells with an approp...

Purpose: To investigate the influence of suppressor cytokine signaling 3 (SOCS3) on rats with colon cancer (CC).
 Methods: Sprague-Dawley (SD) were randomly divided into CC group and control group, then rat model was constructed. The expression SOCS3 in tissues determined by quantitative real time-polymerase chain reaction (qRT-PCR). Hematoxylin-eosin staining (H&E) used to examine tis...

The role of macrophages and of macrophage-lymphocyte co-operation in the induction of T-suppressor cell activity in rats with adjuvant arthritis was investigated. Macrophages from arthritic rats had no direct effect on the induction of T-suppressor cells, but, in the presence of arthritic rats' lymphocytes or supernatants from such lymphocytes, macrophages inhibited the induction of T-suppresso...

Mitotic recombination or nondysjunction are common mechanisms for tumor-specific loss of constitutional heterozygosity (LOH) and tumor suppressor allelic inactivation and can be useful in localizing new putative tumor suppressor genes. In osteosarcoma, the highest frequencies of LOll have been reported for chromosomes 3q, 13q, lip, and lSq. The high incidenceof LOll on chromosome3q suggeststhe ...

Concanavalin-A-induced T-suppressor cell activity was decreased in spleen cell suspensions from Lewis rats with adjuvant arthritis. This decreased activity was evident on day 10 after the induction of the disease, just before the development of the polyarthritic lesions, and persisted during the period of active inflammatory and immunological disease. The extent of the impairment of T-suppresso...

Previously, we reported that Paracoccidioides brasiliensis culture filtrate antigen (Pb.Ag) when injected i.v. into mice induces antigen-specific suppressor cells which down-regulate the anti-P. brasiliensis delayed-type hypersensitivity (DTH) response. The suppressor cells are present in both spleens and lymph nodes of Pb.Ag-treated animals and suppress the afferent limb but not the efferent l...

Suppressor cell activity which was radiosensitive in most subjects and thymic hormone sensitive in some was identified in patients with cancer, and compared to simultaneously studied normal controls. Suppressor cell activity was measured in cocultures of normal lymphocytes with patient lymphocytes added in microwells using the blastogenic response to phytohemagglutinin and concanavalin A as the...