نتایج جستجو برای: suppressive function

تعداد نتایج: 1223809  

2012
James B. Wing Shimon Sakaguchi

Foxp3(+) regulatory T cells (Tregs) are a constitutively immunosuppressive cell type critical for the control of autoimmunity and inflammatory pathology. A range of mechanisms of Treg suppression have been identified and it has not always been clear how these different mechanisms interact in order to properly suppress autoimmunity and excessive inflammation. In recent years it has become clear ...

Journal: :Clinical and Developmental Immunology 2008
Wakae Fujimaki Nozomu Takahashi Kei Ohnuma Masayoshi Nagatsu Hiromi Kurosawa Satoko Yoshida Nam H. Dang Takehiko Uchiyama Chikao Morimoto

CD25(+)CD4(+) regulatory T cells suppress T cell activation and regulate multiple immune reactions in in vitro and in vivo studies. To define the regulatory function of human CD25(+)CD4(+) T cells at various stages of maturity, we investigated in detail the functional differences of CD25(+)CD4(+) T cells from thymocytes, cord blood (CB), and adult peripheral blood (APB). CB CD25(+)CD4(+) T cell...

Background: The ultimate goal of the treatment of infectious knee arthritis is to protect the articular cartilage fromadverse effects of infection. Treatment, however, is not always hundred percent successful and has a 12% failurerate. Persistent infection is more likely to happen in elderly patients and those with underlying joint diseases,particularly osteoarthritis. Eradica...

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