A 70-year-old man presented with slow gait and a clumsy hand on the right side. Neurological examination revealed dystonia ideomotor apraxia in hand. mask-like face, rigidity arm, shuffling were noticed. Treatment L-dopa had no effect. He was clinically diagnosed corticobasal syndrome (CBS). Susceptibility-weighted images of brain magnetic resonance imaging showed low-intensity areas surface ce...

Superficial Siderosis (SS) is a rare neurological condition which results from hemosiderin deposition on the leptomeninges, subpial and ependymal surfaces of the central nervous system (CNS). Patients commonly present with the classic triad of hearing loss, cerebellar ataxia and pyramidal signs. We report clinical, radiological and pathological findings in a patient with SS due to chronic haemo...

BACKGROUND AND PURPOSE Transient focal neurological episodes occur in cerebral amyloid angiopathy (CAA) and can mimic transient ischemic attack (TIA). Risk factors and outcomes of minor ischemic stroke or TIA might differ in patients with and without cerebral microbleeds (CMBs), including CAA-consistent lobar CMB. METHODS Baseline magnetic resonance imaging (MRI) was analyzed for CMBs and cor...

BACKGROUND AND PURPOSE Transient focal neurological episodes (TFNE) are recognized in cerebral amyloid angiopathy (CAA) and may herald a high risk of intracerebral hemorrhage (ICH). We aimed to determine their prevalence, clinical neuroimaging spectrum, and future ICH risk. METHODS This was a multicenter retrospective cohort study of 172 CAA patients. Clinical, imaging, and follow-up data wer...

OBJECTIVES To report the clinical features of two Japanese brothers with familial leptomeningeal amyloidosis, showing a causative gene abnormality of a transthyretin (TTR) variant Asp18Gly, previously reported only in a Hungarian family. METHODS The authors reported on a 42 year old man (patient 1) and his 45 year old brother (patient 2), both suffering from subarachnoid haemorrhage (SAH) wit...