There is a crosstalk between mood disorders and oxidative stress. Chlorpheniramine (CPA), a first generation antihistamine, is hypothesized to have an anxiolytic role at high doses; however, its antidepressant and antioxidant roles have not previously been investigated. The aim of the current study was to evaluate the antidepressant and anxiolytic effects of CPA treatment in association with ni...

The thyroid plasma membrane contains a Ca2(+)-regulated NADPH-dependent H2O2 generating system which provides H2O2 for the thyroid peroxidase-catalyzed biosynthesis of thyroid hormones. The plasma membrane fraction contains a Ca2(+)-independent cytochrome c reductase activity which is not inhibited by superoxide dismutase. But it is not known whether H2O2 is produced directly from molecular oxy...

objective(s): this study describes the preparation, biodistribution of 153sm-dtpa-spion after intravenous injection in rats. materials and methods: the chelator dtpa dianhydride was conjugated to spion using a small modification of the well-known cyclic anhydride method. conjugation was done at a 1: 4 (spion: ccdtpa) molar ratio. conjugation reaction was purified with magnetic assorting column ...

The relative acute toxicity of Dichlorvos and Cypermethrin acting singly against Rainbow crab, Cardiosoma armatum was evaluated. effects sub lethal concentrations the pesticides on oxidative responses histopathological in gills crab were also investigated over a 30 days period. On basis 96 hrs LC50 value, with hr 8.86 ?g/L 2 times more toxic to crabs than 17.80 ?g/L. exposures (1/10th 1/100th L...

BACKGROUND: In cirrhotic livers, the balance of vasoactive substances is in favour of vasoconstrictors with relatively insufficient nitric oxide. Endothelial dysfunction has been documented in cirrhotic rat livers leading to a lower activity of endothelial nitric oxide synthase but this might not be sufficient to explain the low nitric oxide presence. We compared the amount of all nitric oxide ...

Nitric oxide and superoxide are free radicals that appear to contribute to the pathogenesis of a number of brain disorders, and cerebral endothelial cells are a potential target of these agents. Because of the capacity for these two agents to combine, it has been suggested that nitric oxide might either enhance or inhibit the toxic effects of superoxide. To establish the effect of the generatio...

OBJECTIVE Chronic administration of ouabain induces hypertension and increases the contribution of nitric oxide to vasoconstrictor responses in peripheral arteries. The aim of this study was to analyse whether ouabain treatment alters the nitric oxide bioavailability in cerebral arteries. METHODS Basilar arteries from control and ouabain-treated rats ( approximately 8.0 microg/day, 5 weeks) w...

this study aimed to assess the response of chickpea genotypes to drought stress in terms of morphological traits and subsequent biochemical changes to further understanding of drought resistance mechanisms in plants and access to better genetic resources. the chickpea genotypes including mcc776, mcc877, mcc696 and mcc588 evaluated at four soil moisture regimes with field capacity (control), 75%...

Background: Spinal cord injury (SCI) is a traumatic or nontraumatic injury that can leads to loss of functions such as feeling or mobility along with permanent and debilitating influences on the patient’s quality of life. Patients with SCI have weakened sexual function and a distinctive sperm profile described by normal to high sperm concentrations and unusually low sperm mobility. The reason o...