The endoplasmic reticulum (ER) consists of the nuclear envelope and a peripheral network of tubules and membrane sheets. The tubules are shaped by the curvature-stabilizing proteins reticulons and DP1/Yop1p, but how the sheets are formed is unclear. Here, we identify several sheet-enriched membrane proteins in the mammalian ER, including proteins that translocate and modify newly synthesized po...

Merkel cell carcinoma (MCC) is an aggressive poorly differentiated neuroendocrine cutaneous carcinoma associated with older age, immunodeficiency and Merkel cell polyomavirus (MCPyV) integrated within malignant cells. The presence of intra-tumoural CD8+ lymphocytes reportedly predicts better MCC-specific survival. In this study, the distribution of inflammatory cells and properties of CD8+ T ly...

this paper investigates the lateral vibration of single-layered graphene sheets based on a new theory called doublet mechanics with a length scale parameter. after a brief reviewing of doublet mechanics fundamentals, a sixth order partial differential equation that governs the lateral vibration of single-layered graphene sheets is derived. using doublet mechanics, the relation between natural f...

Between the sheets: Sodium-ion batteries are an attractive, low-cost alternative to lithium-ion batteries. Nitrogen-doped porous carbon sheets are prepared by chemical activation of polypyrrole-functionalized graphene sheets. When using the sheets as anode material in sodium-ion batteries, their unique compositional and structural features result in high reversible capacity, good cycling stabil...

The endoplasmic reticulum (ER) often forms stacked membrane sheets, an arrangement that is likely required to accommodate a maximum of membrane-bound polysomes for secretory protein synthesis. How sheets are stacked is unknown. Here, we used improved staining and automated ultrathin sectioning electron microscopy methods to analyze stacked ER sheets in neuronal cells and secretory salivary glan...

Very recently, borophene (atomic-thin two-dimensional boron sheet) has been successfully synthesized on the Ag(111) surface by deposition. Two kinds of structures were found. However, the identification of the monolayer boron sheets grown on the metal substrate, as well as the stability of different 2D boron sheets, is controversial. By performing the first-principles calculations, present stud...

   This paper explores the mechanical properties and fracture analysis of C2N-h2D single-layer sheets using classical molecular dynamics (MD) simulations. Simulations are carried out based on the Tersoff potential energy function within Nose-Hoover thermostat algorithm at the constant room temperature in a canonical ensemble. The influences of boron (B) doping on the mechanical properties, ...

In the helicopter emergency medical service (HEMS), the captain flies without using visual assistance to keep some distance between the helicopter and clouds or obstacles. Under the present conditions, the communication specialist (CS) and the captain of HEMS contact each other and select the safest flight path. With the increase in future requests, conducting safe and effective navigation is a...

Bultmanll's fallluus questiull about presupposition/css excgesis is here taken up afresh and answered by a young Scandinavian scholar who lecturcs in Old Testament at Uppsala and is director oj the new 'Biblicum' institute established there, The paper, which is hased o.n an address given at all 1FES COIlference jor theological students in 1970, first appeared in the IFES journal for theological...

Creativity support systems (CSS) aim enhancing the creativity of users. There is an emerging stream of research in which the effects of CSS on the creative output of 1Robert Zmud was the accepting senior editor for this paper. ISRL Categories: AC07, AC08, AI01, AI0105, AI06, AI07, GB01