نتایج جستجو برای: sulphonylureas
تعداد نتایج: 259 فیلتر نتایج به سال:
Diabetes is characterized by hyperglycaemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in pancreatic islet cell function and/or mass. The extent to which hyperglycaemia per se underlies these alterations remains poorly understood. Here we show that β-cell-specific expression of a human activating KATP channel mutation in adult mice leads to rapid di...
Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mentioned the use of plants in treatment of various human ailments. Medical plants play an important role in the management of diabetes mellitus especially in developing countries where resources are meager. Oral hypoglycemic agents like sulphonylureas and biguanides are still the major p...
An overwhelming increase in metabolic syndrome, i.e., obesity, insulin resistance and dyslipidemia has led to type 2 or insulin-resistant diabetes mellitus assuming epidemic proportions. Currently, there are five distinct classes of oral hypoglycemic agents available. These are – sulphonylureas, meglitinides, biguanides, thiazolidinediones and alpha-glucosidase inhibitors. United Kingdom Prospe...
This review considers the therapeutic choices currently faced by people with type 2 diabetes and those caring for them when glucose levels initially controlled with lifestyle management and metformin start to rise. While sulphonylureas are familiar agents and cheaper than other alternatives, they cause hypoglycaemia and modest weight gain, and robust outcome data are still lacking. Dipeptidyl p...
As illustrated most recently by the controversy surrounding the myocardial infarction risk associated with rosiglitazone, substantial uncertainty remains regarding the effects of different glucoselowering drug classes and, importantly, different drugs within each class on cardiovascular (CV) risk and mortality outcomes in patients with type 2 diabetes (T2DM). In the setting of the ongoing proli...
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