Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. Among them, 13 and 17~22 are new compounds. T...

Curcumin (1) and ten derivatives (2-11) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maxi...

Breast cancer is the most common neoplasm and leading cause of death in women worldwide. Although 5-fluorouracil a conventional chemotherapeutic agent for breast treatment, its use may result severe side effects. Thus, there widespread interest lowering drawbacks, without affecting therapeutic efficacy by concomitant with natural products. Herein, we aimed at evaluating whether α-mangostin, ant...

Novel purine ribonucleoside analogues (9-13) containing a 4-substituted piperazine in the substituent at N(6) were synthesized and evaluated for their cytotoxicity on Huh7, HepG2, FOCUS, Mahlavu liver, MCF7 breast, and HCT116 colon carcinoma cell lines. The purine nucleoside analogues were analyzed initially by an anticancer drug-screening method based on a sulforhodamine B assay. Two nucleosid...

Recently, the abuse of recreational drugs has become an important problem in many countries. Among these psychoactive substances are synthetic cathinones, a group of compounds derived from the alkaloid cathinone, that have gained widespread popularity. Many cathinones have demonstrated neurotoxic effects. The aim of this study was to examine the effects of 3-fluoromethcathinone, a structural an...

The ethanolic extract from stems and leaves of Diospyros gracilipes Hiern showed moderate antimicrobial activity against Staphylococcus aureus (9 mm), Klebsiella pneumonia (7 mm) and Candida albicans (11 mm) using the disc diffusion assay. Fractionation of the extract led to the isolation of lupenone, ursolic acid, corosolic acid, a mixture of 3αand 3βtaraxerols, 3β-E-coumaroyltaraxerol, pinoce...

Cholangiocarcinoma (CCA) is a malignant tumor arisen from bile duct epithelial cells. Liver fluke (Opisthorchis viverrini) infection is considered as a main cause of CCA in Northeast Thailand. Low Se intake has been found to be associated with the high risk of several cancers. The chemotherapeutic and chemopreventive potentials of several selenium compounds have been studied and proved in many ...

iv CHAPTER 1. GENERAL INTRODUCTION 1 Current reporter genes 1 Fluorescent proteins 3 In Vivo Imaging 6 RNA Imaging 8 Aptamers 9 Aptamer structure and stabilization 10 Applications of aptamers 11 Riboswitches natural RNAs with aptamer-like properties 12 Application of aptamers for imaging 13 Sulforhodamine-B and fluorescein aptamers 13 Fluorescence switches and “Light-up” aptamers 14 Theophyllin...

Purpose: To determine the antioxidant and anticancer effects of Piper betle (P. betle) leaf extract on human breast cancer MCF-7 cells, to develop transdermal patches containing extract.
 Methods: The P. was prepared by maceration method, its activity evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Cytotoxicity suppression cell migration (indices activity) w...

Column chromatographic isolation of the MeOH extract of the seeds of Amomum xanthioides afforded a new diterpene glycoside, amoxanthoside A (1), two new monoterpene glycosides, (1 S,4 S,5 S)-5- EXO-hydroxycamphor 5-O-beta-D-glucopyranoside (2) and (1 R,4 R,5 S)-5-ENDO-hydroxycamphor 5-O-beta-D-glucopyranoside (3), together with four known compounds, hedychiol A (4), pygmol (5), (1 S,4 R,6 R)-(+...