Solitary rectal ulcer causing lower gastrointestinal bleeding is extremely rare in children. Rare presentation, non-specific symptoms, insufficient experience, and characteristics mimicking other rectal diseases may cause misdiagnosis or delay of diagnosis in some pediatric patients. Here, we report a 10-year-old boy with solitary rectal ulcer diagnosed two years after onset of the symptoms who...

A 48-year-old man who complained of a severe throbbing pain in his right lateral chest was referred to our department. His chest computed tomography (CT) and X-ray, abdominal CT and ultrasonography had revealed no abnormalities. Four days after admission to our ward the patient vomited and he requested upper gastrointestinal (GI) endoscopy: this showed duodenal ulcer. Treatment with omeprazole ...

We present the case of a 42-year-old woman with spina bifida and paraplegia who was referred to us because of chronic discomfort related to erosions and ulcerations of her perineal area, buttocks, and upper posterior thighs (Figure 1). Twenty years previously she had an ileal diversion and urostomy resulting in chronic urethral discharge and diarrhea for 5 years. She required a diaper constantl...

Consider a protocol to identify patients needing prophylaxis inthe ICU Many patients may enter the hospital already on a PPI for reflux disease or prevention of gastrointestinal side effects from other medications. This Clinical Inquiry shows that only certain patients in the hospital will benefit from prophylaxis for stress ulcers and have less bleeding. Therefore, consider using a protocol to...

Objective: Aceclofenac is a phenylacetic acid derivative; this nonsteroidal anti-inflammatory drug is a potent anti-inflammatory analgesic and antipyretic. The objectives of this study were to conduct a pharmacokinetic study of aceclofenac in a Pakistani population, to compare the pharmacokinetic profile of the local population with the United Kingdom (UK) and to determine the effect of sucralf...

Sucralfate, a complex polyaluminium hydroxide salt of polysulphated sucrose, is used in medical treatment of peptic disease as a coating agent that provides a protective barrier to further damage from acid and pepsin. Its actions are principally local and at acid pH becomes highly polar and binds by way of strong electrostatic interaction to ulcer tissue for up to 12 hours, while relatively lit...