A novel family of thiazolo[5,4-d]thiazole (TzTz) fluorophores having a general formula (py)n-?-TzTz-?-(py)n (n = 1 or 2, py pyridine) is herein reported. The investigated compounds are decorated with alkoxy-substituted pyridine scaffolds bearing chains different lengths (a methoxy, b 2-ethylhexan-1-oxy, c 2-decyltetradecan-1-oxy) that connected at either the para- meta-position(s) phenyl bridgi...

During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds was prepared using the Groebke reaction and a subset of compounds prepared from 2-chlorobenzaldehyde, cyclohexyl isocyanide and a 6-substituted 2-aminopyridine showed good inhib...

A straightforward synthesis of 6-substituted 1-phenyl-3-trifluoromethyl-1H-pyrazolo[4,3-c]pyridines and the corresponding 5-oxides is presented. Hence, microwave-assisted treatment of 5-chloro-1-phenyl-3-trifluoromethylpyrazole-4-carbaldehyde with various terminal alkynes in the presence of tert-butylamine under Sonogashira-type cross-coupling conditions affords the former title compounds in a ...

Hydroxamates derived from 3-sulfolene-3‑carboxylic acid can be involved in intra- and intermolecular rhodium(III)-catalyzed heteroannulations with alkynes proceeding via C(sp 2 )–H bond activation. These transformations allow a straightforward access to diversely substituted pyridones, pyridines fused sulfolene ring after functional group transformations. Subsequent cheletropic elimination of s...

The reactions of 2- or 4-cyanopyridinium salts with active methylene compounds such as dimethyl malonate, malononitrile, and cyclohexane-1,3-dione affording 2- or 4-(substituted methylene) pyridines are described. Similar reactions of 4-cyano-2-methylthiopyridinium and 4-cyano-2-methylthioquinolinium salts, both of which have two leaving groups, were readily prepared from 4-cyano-1-methyl-2(1H)...

In the present study, a series of 2-(3'-substituted-2'-hydroxypropylamino)pyridines were synthesized and characterized by IR, 1H-NMR and elemental analysis. The compounds were investigated for anticonvulsant (150, 300 mg/kg) and cardiac activity. 2-(3'-Diethylamino-2'-hydroxypropylamino)pyridine 3 was found to exhibit the highest anticonvulsant activity. 2-(3'-Dimethylamino-2'-hydroxypropylamin...

A series of eight 5-aryl/heteryl-7,8,13,14-tetrahydrodibenzo[a,i]phenanthridines, another series of seven novel 5aryl/heteryl-1,2,3,6,7,8-hexahydrodicyclopenta[b,d]pyridines and two hitherto unknown bridged 2,4-diaryl-3azabicyclo[3.2.1]octan-8-ones have been synthesised by the condensation of α-tetralone and various aryl/heteryl aldehydes, cyclopentanone and same aryl/heteryl aldehydes and cycl...