Clostridium perfringens iota-toxin is a binary toxin composed of an enzymatic component (Ia) and a binding component (Ib). The oligomer of Ib formed in membranes induces endocytosis. We examined the binding and internalization of Ib by using Cy3-labeled Ib. Labeled Ib was retained at the membranes of MDCK cells for 60 min of incubation at 37 degrees C, and later it was detected in cytoplasmic v...

BACKGROUND To determine the effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy. METHODS PubMed, Web of Science, ProQuest and Medline were searched using the key words "cervical cancer", "locally advanced disease", "radiotherapy" and "surgery or hysterectomy". Eight articles were selected and analysed using the STATA ...

Abstract. A subgroup H of a group G is said to be SS-embedded in G if there exists a normal subgroup T of G such that HT is subnormal in G and H T H sG , where H sG is the maximal s- permutable subgroup of G contained in H. We say that a subgroup H is an SS-normal subgroup in G if there exists a normal subgroup T of G such that G = HT and H T H SS , where H SS is an SS-embedded subgroup of ...

OBJECTIVES Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. MATERIALS AND METHODS Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7...

Nociceptive dorsal root ganglion (DRG) neurons can be classified into nonpeptidergic IB(4)(+) and peptidergic IB(4)(-) subtypes, which terminate in different layers in dorsal horn and transmit pain along different ascending pathways, and display different firing properties. Voltage-gated, tetrodotoxin-resistant (TTX-R) Na(v)1.8 channels are expressed in both IB(4)(+) and IB(4)(-) cells and prod...

Background: Plasmid mediated quinolone resistance (PMQR) has been shown to play an important role in resistance not only to quinolones, but also β-lactams and aminoglycosides. In fact, qnr genes are frequently carried along with β-lactamase determinants on the same plasmids. We studied the prevalence of qnrA, qnrB, qnrS and aac(6’)-Ib-cr genes among quinolone and cephalosporin resistant clinica...

we call $h$ an $ss$-embedded subgroup of $g$ if there exists a‎ ‎normal subgroup $t$ of $g$ such that $ht$ is subnormal in $g$ and‎ ‎$hcap tleq h_{sg}$‎, ‎where $h_{sg}$ is the maximal $s$-permutable‎ ‎subgroup of $g$ contained in $h$‎. ‎in this paper‎, ‎we investigate the‎ ‎influence of some $ss$-embedded subgroups on the structure of a‎ ‎finite group $g$‎. ‎some new results were obtained.

let $h$, $l$ and $x$ be subgroups of a finite group$g$. then $h$ is said to be $x$-permutable with $l$ if for some$xin x$ we have $al^{x}=l^{x}a$. we say that $h$ is emph{$x$-quasipermutable } (emph{$x_{s}$-quasipermutable}, respectively) in $g$ provided $g$ has a subgroup$b$ such that $g=n_{g}(h)b$ and $h$ $x$-permutes with $b$ and with all subgroups (with all sylowsubgroups, respectively) $v$...

Clostridium perfringens type E iota toxin consists of two unlinked proteins designated as iota a (Ia; molecular mass approximately 47 kDa), an ADP-ribosyltransferase and iota b (Ib; molecular mass approximately 81 kDa) which binds to the cell surface and facilitates Ia entry into the cytosol. By Western-blot analysis, Ib incubated with Vero cells at 37 degrees C generated a cell-associated, SDS...