L-, Nand P-lQ-type voltage-dependent calcium channels share a common structure, and are composed o f a t least one primary a, subunit and auxiliary P and a26 subunits. Expression o f the a, subunit alone in mammalian cells usually results in small calcium currents, and these are increased many times in amplitude by coexpression o f auxiliary P and a26 subunits. The P subunit, a cytoplasmically ...

Informal exchanges between friends, family and acquaintances play a crucial role in the dissemination of news and opinion. These casual interactions are embedded in a network of communication that spans our society, allowing information to spread from any one person to another via some set of intermediary ties. Weblogs have recently emerged as a part of our media ecology, and incidentally engen...

The recognition of β-barrel membrane proteins based on their sequence is more challenging than the recognition of α-helical membrane proteins. This goal could benefit from a better understanding of the physical determinants of transmembrane β-barrel structure. To that end, we first extend the IMM1 implicit membrane model in a way that allows the modeling of membrane proteins with an internal aq...

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We investigate how people use causal knowledge to design interventions to affect the outcomes of causal systems. We propose that in addition to using content or mechanism knowledge to evaluate the effectiveness of interventions, people are also influenced by the abstract structural properties of a causal system. In particular, we investigated two factors that influence whether people tend to in...

BACKGROUND & OBJECTIVE Health impact assessment (HIA) offer a very logical and interesting approach for those aiming to integrate health issues into planning processes. With a lot of works and plans waiting to be done (e.g., developing and updating plans, counseling planning commissions, cooperation with other organizations), planners find it difficult to prioritize health among a variety of po...

Gender-based inequalities in health have been frequently documented. This paper examines the extent to which these inequalities reflect the different social experiences and conditions of men's and women's lives. We address four specific questions. Are there gender differences in mental and physical health? What is the relative importance of the structural, behavioural and psychosocial determina...

BACKGROUND Research capacity building and its impact on policy and international research partnership is increasingly seen as important. High income and low- and middle-income countries frequently engage in research collaborations. These can have a positive impact on research capacity building, provided such partnerships are long-term collaborations with a unified aim, but they can also have ch...

BACKGROUND The relationship between social capital and self-rated health has been documented in many developed compared to developing countries. Because social capital and health play important roles in development, it may be valuable to study their relationship in the context of a developing country with poorer health status. Further, the role of social capital research for health policy has n...

The social determinants of health (SDH) are recognized as important indicators of health and well-being. Health-care services (primary, secondary, tertiary care) have not until recently been considered an SDH. Inequities in access to health care are changing this view. These inequities include barriers faced by certain population groups at point of care, such as the lack of cultural competence ...