نتایج جستجو برای: stretch

تعداد نتایج: 16103  

Journal: :CoRR 2014
Michael B. Cohen Gary L. Miller Jakub W. Pachocki Richard Peng Shen Chen Xu

We give a generalized definition of stretch that simplifies the efficient construction of lowstretch embeddings suitable for graph algorithms. The generalization, based on discounting highly stretched edges by taking their pth power for some 0 < p < 1, is directly related to performances of existing algorithms. This discounting of high-stretch edges allows us to treat many classes of edges with...

Journal: :PLoS ONE 2008
Bin Wei Zheng Chen Xu Zhang Morris Feldman Xian-zhi Dong Robert Doran Bao-Lu Zhao Wen-xuan Yin Michael I. Kotlikoff Guangju Ji

BACKGROUND Hollow smooth muscle organs such as the bladder undergo significant changes in wall tension associated with filling and distension, with attendant changes in muscle tone. Our previous study indicated that stretch induces Ca(2+) release occurs in the form of Ca(2+) sparks and Ca(2+) waves in urinary bladder myocytes. While, the mechanism underlying stretch-induced Ca2+ release in smoo...

Journal: :Biophysical journal 2008
Núria Gavara Pere Roca-Cusachs Raimon Sunyer Ramon Farré Daniel Navajas

The mechanical properties of the living cell are intimately related to cell signaling biology through cytoskeletal tension. The tension borne by the cytoskeleton (CSK) is in part generated internally by the actomyosin machinery and externally by stretch. Here we studied how cytoskeletal tension is modified during stretch and the tensional changes undergone by the sites of cell-matrix interactio...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Wei Zheng Lance P Christensen Robert J Tomanek

We previously demonstrated that cyclic stretch of cardiac myocytes activates paracrine signaling via vascular endothelial growth factor (VEGF) leading to angiogenesis. The present study tested the hypothesis that cyclic stretch upregulates tyrosine kinase receptors in rat coronary microvascular endothelial cells (RCMEC) and human umbilical vein endothelial cells (HUVEC). VEGF receptor-2 (Flk-1)...

2015
Zhuoxin Allen Li Sirkka L. Jarvenpaa

In traditional organizations, stretch goals difficult and seemingly unattainable goals have been much debated for their paradoxical effects. Recently, their use as a managerial instrument in IT-mediated crowds has increased. Using online crowdfunding on Kickstarter as an example, we investigate how the use of stretch goals influences project performance. Empirical results show that the use of s...

Journal: :The American journal of physiology 1960
G BURNSTOCK C L PROSSER

BURNSTOCK, GEOFFREY AND C. L. PROSSER. Responses of smooth muscles to quick stretch; relation of stretch to conduction. Am. J. Physiol. rg8(5) : g21--93:s. I g6o.-Quick stretches applied to isolated strips of visceral muscles elicit contractions and electrical responses, similar stretches elicit no responses from blood vessels and nictitating membrane. Highly excitable muscles gave repetitive r...

Journal: :American journal of physiology. Cell physiology 2016
Song Gao James A Carson

Mechanical stretch can activate muscle and myotube protein synthesis through mammalian target of rapamycin complex 1 (mTORC1) signaling. While it has been established that tumor-derived cachectic factors can induce myotube wasting, the effect of this catabolic environment on myotube mechanical signaling has not been determined. We investigated whether media containing cachectic factors derived ...

Journal: :American journal of physiology. Heart and circulatory physiology 2000
J H Jiao P Baumann A Baron A Roatti R A Pence A J Baertschi

Stretch-induced atrial natriuretic factor (ANF) secretion was studied in cultures of neonate atrial appendage myocytes. Stretch, applied for 40 min by hypotonic swelling, increased the mean area of 44 individually imaged myocytes by 4.8-8.8% (P < 0.0001) at 6 min and by 2.3-6.2% (P < 0.05) at 35 min. Stretch increased immunoreactive ANF release by 42% (P < 0.05) from a baseline of 315 pg/ml. Th...

Journal: :The Journal of experimental biology 2004
Yoshiki Ishii Takashi Watari Teizo Tsuchiya

We investigated the mechanism of the enhancement of twitch force by stretch and the effects of temperature on it in nerve-skeletal muscle preparations of whole iliofibularis muscles isolated from the frog Rana brevipoda. When a preparation was stimulated indirectly and stretched, the twitch force after the stretch was enhanced remarkably in comparison to that observed before a stretch at low te...

1999
PAUL R. STANDLEY TAMAR J. OBARDS Tamar J. Obards

Standley, Paul R., Tamar J. Obards, and Cherie L. Martina. Cyclic stretch regulates autocrine IGF-I in vascular smooth muscle cells: implications in vascular hyperplasia. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E697–E705, 1999.—Vascular smooth muscle cells (VSMC) subjected to acute or chronic stretch display enhanced growth rates in vitro and in vivo. Clinical examples of vascular hyperpla...

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