The autoimmune cascade that culminates in diabetes initiates within pancreatic lymph nodes (PLNs). Here, we show that developmentally controlled lymphogenesis establishes a preferential trafficking route from the gut to the PLN, where T cells can be activated by antigens drained from the peritoneum and the gastrointestinal tract. Furthermore, intestinal stress modifies the presentation of pancr...

We report about a 49 year old woman with repeated chest pain at rest. During hyperventilation significant ST-segment elevation in leads V1-V5 appeared. Bicycle stress test did not provoke any ECG changes. Coronary angiography showed a significant stenosis of the left anterior descending coronary artery. Successful balloon angioplasty followed by stent implantation was performed. After an uneven...

Stress and stress-related health impairments are major problems in human life and elucidating the biological pathways linking stress and disease is of substantial importance. However, the identification of mechanisms underlying a dysregulation of major components of the stress response system is, particularly in humans, a very challenging task. Salivary cortisol responses to diverse acute chall...

OBJECTIVE The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD. METHOD Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength. RESULTS PTSD subjects showed significantly less ...

OBJECTIVE To identify factors, particularly the growth hormone (GH) provocation test result, affecting growth response to GH treatment in children with GH deficiency (GHD). SUBJECTS A total of 337 prepubertal GHD patients aged <10 years from the UK Pharmacia KIGS database (GH response to provocation test <20 mU/l). OUTCOME MEASURE Annual change in height standard deviation score (SDS) (revi...

BACKGROUND Minimal persistent inflammation (MPI) contributes to hyperreactivity in allergic rhinitis. However, little is known regarding whether pre-onset activation of eosinophils and mast cells is present or not in Japanese cedar pollinosis (JCP). Furthermore, a prophylactic effect of intranasal corticosteroids on such MPI in JCP has not been investigated. METHODS We designed a double-blind...

Occupational asthma due to platinum salts is a frequent disease in platinum refineries. The diagnosis is based upon a history of work related symptoms and a positive skin prick test with platinum salts. Bronchial provocation tests have not been performed in epidemiological studies because the skin test is believed to be highly specific and sensitive. As no reliable data about this issue current...

Emerging research suggests that rumination increases risk for negative health outcomes. In the first experiment to investigate cortisol responses during angry rumination, participants were provoked and induced to engage in self-focused rumination, provocation-focused rumination, or distraction. Consistent with social threat theory, self-focused rumination maintained high levels of cortisol foll...

Two studies examined the interaction between the presence or absence of (a) an initial provocation and (b) a subsequent minor triggering action on the part of the target of displaced aggression. Consistent with the triggering event being seen by participants as indeed trivial when administered by itself without prior provocation, exposure to it literally had no impact on aggression toward its s...

Why do people behave aggressively toward romantic partners, and what can put the brakes on this aggression? Provocation robustly predicts aggression in both intimate and nonintimate relationships. Four methodologically diverse studies tested the hypothesis that provocation severity and relationship commitment interact to predict aggression toward one’s romantic partner, with the aggression-prom...