Several analytical methods have been suggested for the determination of mannosidostreptomycin (streptomycin B) (5, 6). Titus and Fried (6, 12) and Plaut and McCormack,’ who have utilized the quite specific and quite accurate but yet laborious counter-current distribution methods (previously described by Craig) for the isolation and determination of streptomycin B, have noted a number of difficu...

The growth rates of streptomycin-dependent mutants varied in proportion to the level of streptomycin supplied; growth also varied characteristically from one dependent strain to another at a given streptomycin concentration. When cells growing at different rates (over a threefold range) were treated with rifampin, direct proportionality was observed for three parameters: (i) the rates of shutof...

OBJECTIVES To evaluate the inexpensive colorimetric nitrate reductase-based antibiotic susceptibility (CONRAS) assay for testing the susceptibility of Mycobacterium tuberculosis to streptomycin and ethambutol in liquid cultures, and to compare the CONRAS test with the manual mycobacteria growth indicator tube (MGIT) test, using the radiometric BACTEC 460TB method as reference. METHODS A total...

The clinical application of streptomycin, as for any other potent drug, requires reliable information on blood levels of the drug. Microbiological assays will give estimates subject to wide variations unless a sufficient number are performed to permit statistical evaluation. The need for a reasonably simple and reproducible chemical assay for streptomycin in blood is apparent. We have previousl...

In previous reports (Elberg and Herzberg, 1953; Herzberg and Elberg, 1953) the isolation and characteristics of a streptomycin-dependent mutant of Brucella melitenis were described.2 The streptomycin-dependent strain retained the biochemical and antigenic characteristics of the virulent parent strain but differed in a requirement for streptomycin for its growth. Growth in vivo was not influence...

In previous communications (3-5) I have reported, among other things, that 4-4'-diaminodiphenyl sulfone (DDS), streptomycin, and isoniazid (isonicotinic acid hydrazide) possess definite therapeutic activity in mouse leprosy, and that the combination of DDS and streptomycin showed an additive effect. The effects of various combinations of DDS, streptomycin and isoniazid on mouse leprosy are repo...

form of recent dental infection or manipulation.4 Our patient also had very poor dentition and valvular heart disease. Various combinations of antibiotics like penicillin and streptomycin, cephalosporin and streptomycin, penicillin, tetracycline and streptomycin have been successful in achieving cure, however, at present high dose penicillin (> 25 mU/day) in combination with an aminoglycoside f...

Objective: Streptomycin is the preferred choice for therapy of plague in China and other countries. However, Yersinia pestis exhibiting plasmid-mediated antimicrobial agent–resistant traits had been reported Madagascar. In this study, we evaluated susceptibility traditional or newer agents used treatment and/or prophylaxis plague. Methods: Following Clinical Laboratory Standards Institute (CLSI...

The effect of x-rays on the rickettsiostatic activity of streptomycin, penicillin and aureomycin in the embryonate egg was investigated. Only a slight reversal of the rickettsiostatic action of 5 mg. of streptomycin occurred in embryonate eggs given 100 r of x-rays at 4 days of incubation, whereas complete reversal occurred in those given 1000 r. Groups of eggs irradiated with intermediate dose...