This paper proposes a simplified approach to the assembly of large physical genome maps. The approach focuses on two key problems: (i) the integration of diverse forms of data from numerous sources, and (ii) the detection and removal of errors and anomalies in the data. The approach simplifies map assembly by dividing it into three phases-overlap, linkage and ordering. In the first phase, all f...

This paper describes experiments designed to evaluate Na+ and C1transport in isolated proximal straight tubules from rabbit kidneys. When the perfusing solution was Krebs-Ringer buffer with 25 mM HCO8 (KRB) and the bath contained KRB plus 6 % albumin, net volume reabsorption (J,, nl min-' mm-') was -0.46 4 0.03 (SEM); V., the spontaneous transepithelial potential difference, was -1.13 + 0.05 mV...

Common belief has it that people who get lost in unfamiliar terrain often end up walking in circles. Although uncorroborated by empirical data, this belief has widely permeated popular culture. Here, we tested the ability of humans to walk on a straight course through unfamiliar terrain in two different environments: a large forest area and the Sahara desert. Walking trajectories of several hou...

THE connection illustrated (fig. 1) has been found useful when administering anaesthetics in the following circumstances : FIG. 2 It is probable that the idea of a similar connection has occurred to others. No mention of one, however, could be found in the literature nor did the anaesthetic instrument firms know of one. The screw Fio. 1 Cranial Angiography. Here (fig. 2) it is essential that th...

SU-8 can be patterned with high resolution, is flexible and tough. These characteristics qualify SU-8 as a material for making spotting pins for printing DNA and protein microarrays, and it can potentially replace the commonly used silicon and steel pins that are expensive, brittle in the case of silicon and can damage the substrate during the printing process. SU-8, however, accumulates large ...

Hedging foreign currency risk is a central task for treasuries of multinational corporations. Traditionally, it has strongly relied on voice-based broking. With the advent of Internet technology, online platforms for foreign exchange trading emerged offering corporations a single point of access to the liquidity of a global market. However, online marketplaces only become truly valuable if seam...

Net Asset Value (NAV) calculation and validation is the principle task of a fund administrator. If the NAV of a fund is calculated incorrectly then there is huge impact on the fund administrator; such as monetary compensation, reputational loss, or loss of business. In general, these companies use the same methodology to calculate the NAV of a fund, however the type of fund in question dictates...

We introduce the concept of a constrained pointed pseudo-triangulation TG of a point set S with respect to a pointed planar straight line graph G = (S,E). For the case that G forms a simple polygon P with vertex set S we give tight bounds on the vertex degree of TG.