PURPOSE To evaluate the predictive value of the disintegrin and metalloproteinases, ADAM-9, ADAM-10, ADAM-11, and ADAM-12, and of the matrix metalloproteinases, MMP-2 and MMP-9, in patients with recurrent breast cancer treated with tamoxifen. EXPERIMENTAL DESIGN A retrospective study was done on 259 frozen specimens of estrogen receptor-positive primary breast carcinomas from patients who dev...

Matrix metalloproteinases (MMPs) influence synaptic recovery following traumatic brain injury (TBI). Membrane type 5-matrix metalloproteinase (MT5-MMP) and a distintegrin and metalloproteinase-10 (ADAM-10) are membrane-bound MMPs that cleave N-cadherin, a protein critical to synapse stabilization. This study examined protein and mRNA expression of MT5-MMP, ADAM-10, and N-cadherin after TBI, con...

ownload isintegrin and metalloproteinase-12 (ADAM-12), a member of multifunctional family of proteins, is lated in many cancers, including breast, lung, liver, prostate, gastric, and bladder. The multidomain re, composed of a prodomain, a metalloproteinase, disintegrin-like, epidermal growth factor–like, cysteined transmembrane domains, and a cytoplasmic tail, allows ADAM-12 to promote matrix d...

in this paper a simple model of a three story building with inclined first-story columns has presented. the stories are supposed to be rigid and are connected to axially rigid mass less columns by elasto-plastic rotational springs and linear rotational dampers. the considered model is subjected to horizontal component of fault normal pulse with different magnitudes and the governed nonlinear di...

introduction: andropause is a common clinical entity of advanced age, with a decline in androgen levels in males. many of the signs of male aging are results of this condition with significant decline in their quality of life and adverse effects on multiple organ systems function. androgen deficiency of the aging male (adam) questionnaire is one of the most applied screening tools for androgen ...

Although story mapping strategy has been shown to be beneficial in many reading comprehension classes, the benefits of this technique have not been thoroughly investigated in L2 writing research. The small number of previous studies (e.g., Li, 2007; Brunner, 2010) have found the potential benefits of using story mapping strategy on students’ writing performance, but they did not focus on differ...

Eliza Rybska, Zbigniew Adamski 2, 3 Antoni Wójcik and Jerzy Błoszyk 5, 6 The Faculty Laboratory for Teaching Biology and Natural Science. Faculty of Biology, Adam Mickiewicz University, Poznan, Poland, Electron and Confocal Microscope Laboratory/ Department of Animal Physiology and Developmental Biology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland Quantum Electronics Laborato...