HyBeacon probes have been used to characterise SNPs in the CYP2C9 and VKORC1 genes associated with variations in the efficiency of warfarin metabolism. PCR amplification of genomic DNA and probe target melting analysis provided a robust and reliable method to differentiate polymorphic sequences at these loci. Probes capped with 5'-trimethoxystilbene were found to exhibit larger fluorescence dif...

The aqueous reversible addition fragmentation chain-transfer (RAFT) copolymerization of isoprene and bulky comonomers, an acrylate and an acrylamide in the presence of methylated β-cyclodextrin was employed for the first time to synthesize block-copolyrotaxanes. RAFT polymerizations started from a symmetrical bifunctional trithiocarbonate and gave rise to triblock-copolymers where the outer pol...

In this paper we introduce a new embedding technique to linearly project labeled data samples into a new space where the performance of a Nearest Neighbor classifier is improved. The approach is based on considering a large set of simple discriminant projections and finding the subset with higher classification performance. In order to implement the feature selection process we propose the use ...

The algorithm of practical application researches results speed changes management devices with a gear differential and the stopper rotational movement in form closed-loop hydraulic system has been described. An example is single-stage single-row differential, when driving link sun gear, driven ring control carrier. For such device, order execution design steps described procedure change design...

Then theircontentswere assayedfor vitamins E and A. Our results all agreed, within theerror of the methods, showing that neither Venojet nor Vacutainer Tube stoppers of the types available in South Africa contain dyes or antioxidants interfering with the assay of vitamin E, in agreement with the work of Sinclair and Slattery (1), or with the assay of vitamin A. Althoughthese results indicate th...

A reversed-phase liquid chromatographic method combined with fluorescence and multiple mass spectrometric detection in series is presented for the separation and structure elucidation of bisphenol A diglycidyl ether (BADGE) and novolac glycidyl ether (NOGE) derivatives. Atmospheric pressure chemical ionization in the positive ion mode and collision induced fragmentation in the ion trap allowed ...