or microscopic in the wall of stomach and bowel. No abnormality of the digestive juices in the small intestine has been recorded. In the stomach, however, there would appear to be some interference with normal function. Marriott' found in cases of coeliac disease that there was a marked deficiency of free hydrochloric acid in the gastric juice and that this gradually returned to normal limits a...

Endoscopic full-thickness resection combined with laparoscopic surgery was recently developed. These procedures could be categorized as "Cut first and then suture" and "Suture first and then cut". "Cut first and then suture" includes laparoscopic and endoscopic cooperative surgery (LECS) and laparoscopy-assisted endoscopic full-thickness resection (LAEFR). Recent studies have demonstrated the s...

The ingestion of nucleic acids (NAs) as a nutritional supplement or in genetically modified food has attracted the attention of researchers in recent years. Discussions over the fate of NAs led us to study their digestion in the stomach. Interestingly, we found that NAs are digested efficiently by human gastric juice. By performing digests with commercial, recombinant and mutant pepsin, a prote...

In Part I, it expands the initial Phase I work by evaluating the roles of various co-constituents that could be present in drinking water or in stomach fluids to determine their affect on the rates of reaction in simulated gastric juice at low pH and in the presence of chloride and hydrogen sulfide. The issue being investigated was whether bromate could be decomposed to some degree in the stoma...

AIM To study the effect of known interference in the measurement of urea and ammonium concentrations in samples of gastric juice. METHODS The effect of pH and ammonium concentration on the o-pthalaldehyde method, the diacetylmonoxime method, a Berthelot linked method and an enzymatic urease method for the measurement of urea in gastric juice was therefore conducted. An enzymatic method of the...

A previous paper (2) described the isolation and crystallization of gastricsin from human gastric juice and the physical, chemical, and enzymatic properties of gastricsin as compared to human pepsin. It is the purpose of the present report to describe the purification and properties of a zymogen from human gastric mucosa. The activation of this zymogen produces both gastricsin and human pepsin.

Estimation of gastric acidity has long been regarded as an essential investigation in patients in whom pernicious anaemia is suspected. Gruel, alcohol, insulin, and small doses of histamine which were earlier used to enhance gastric secretion have been replaced by the augmented histamine test meal introduced by Kay (1953). The introduction of methods for direct assay of the content of intrinsic...

In chronic hypochromic anaemia the mean pepsin concentration of the gastric juice is reduced and in some patients the enzyme is totally absent (Davies, 1931; Castle, Heath, and Strauss, 1931; Meulengracht, 1932; Hartfall and Witts, 1933; Griffiths, 1934; Mullins and Flood, 1935; Aitken, Spray, and Walters, 1954). Aitken et al. (1954) divide their patients into those with and without achlorhydri...

The radiotriolein test has been reported to be unreliable in the diagnosis of steatorrhoea. A possible explanation is provided by these studies in which labelled triolein was incubated in human gastric juice, duodenal juice, and faeces; the bond was not stable on duodenal juice.

I'HE patient who complains of abdominal pain related to food is often referred for an X-ray examination. Among other things, the barium meal will show the rate of emptying of the stomaclh. In some there will be no delay, but in others there will be retention of barium in the stomach six hours after the meal. A few cases of this nature have been collected, in which fractionial test-meals were al...