a laboratory stirred tank bioreactor with six single and dual-impeller configurations was tested to obtain the optimum operating conditions for future biological processes. six impeller combinations consisting of three basic impeller types, namely rushton turbine (rt), pitched 4blade (p4b) and pitched 2blade (p2b) downward flow were investigated in 1.77 l bioreactor working volume. power consum...

Multipurpose stirring and blending vessels equipped with various impeller systems are indispensable in the pharmaceutical industry because of high flexibility necessary during multiproduct manufacturing. On other hand, process scale-up scale-down development transfer from bench or pilot to manufacturing scale, design so-called models (SDMs), is a difficult task due geometrical differences used ...

Traditional viral vector processes rely on lab-scale methods that need to be industrialised so as avoid supply shortages during commercialisation of cell and gene therapies such CAR T-cell HSC therapies. This paper describes the application a decisional tool identify most cost-effective scalable culture technologies used in manufacture lentiviral vectors (LVs) across range products. The consist...

we investigated neuronal uptake of noradrenaline (na) at the level of larger vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear vein) in a model devised to mimic heart failure. the model presented here is the rabbit coronary ligation model in which myocardial infarction w...

results color doppler usg had a sensitivity of 95% and specificity of 98% in diagnosis of arterial injury. positive and negative predictive values of doppler usg were 92.5% and 94.2%, respectively. conclusions color doppler usg can be used as a reliable modality with acceptable sensitivity and specificity values to screen hemodynamically stable patients with limb trauma suspicious for arterial ...

conclusions following cabg, the most severity of pain was reported at surgical incision on time t2. pain began to decrease from the third day following the operation. age, sex and bmi along with operation-related factors such as duration of cbp or chest tube drainage may affect the pain pattern following cabg surgery. patients and methods the present study was conducted on 138 patients who unde...

The non-isothermal continuous stirred tank reactor (CSTR) is a classical yet complex case study of nonlinear dynamical systems. Power-shaping control is a recent approach for the control of nonlinear systems based on the physics of the dynamical system and it rests on the formulation of the dynamics in the Brayton-Moser form. The Brayton-Moser formulation of the non-isothermal continuous stirre...

traumatic coronary artery-cameral fistulas (tcaf) are rare and may present secondary to penetrating injuries (80%) or iatrogenic traumas. early operative intervention remains the recommended treatment modality for accidental traumatic coronary artery fistulas. we report the case of a 17-year-old man who presented with left anterior descending coronary artery-right ventricle fistula following pe...

aneurysms of the left main coronary artery are exceedingly rare clinical entities, encountered incidentally in approximately 0.1% of patients who undergo routine angiography. the most common cause of coronary artery aneurysms is atherosclerosis. angiography is the gold standard for diagnosis and treatment. depending on the severity of the coexisting coronary stenosis, patients with left main co...

results the mean ages in case and control groups were 60.8 ± 6.8 and 57.5 ± 11.5 years, respectively, with no significant difference (p = 0.09). thirty patients (54.5%) in case and 32 (58.2%) in control groups were male with no significant difference (p = 0.7). cmv-dna was present in 8 (14.5%) of the cases and 2 (4%) of the controls. cmv-dna was associated with higher risk of atherosclerosis (o...