OBJECTIVES To describe the efficacy, safety, and exposure-response relationship of canakinumab in a subgroup of patients with systemic juvenile idiopathic arthritis (SJIA) aged ≥16 years, representative of adult-onset Still's disease (AOSD) patients, and to compare this subgroup with those of children and young adolescents with SJIA by pooling clinical data collected during the development prog...

Introduction The greater part of the literature on the occurrence of amyloidosis in rheumatoid arthritis and in Still's disease comes from the Western Hemisphere. Since the recent publication in this country of such a case by Yeoman and Wilson (1947) the interest of rheumatologists on this side of the Atlantic has been awakened and a watch has been kept for further cases. Over 200 cases of rheu...

Parents of 135 children with juvenile rheumatoid arthritis (JRA) completed a mailed questionnaire about problems at school. Writing was the most frequently reported difficulty, with hand involvement causing more problems than decreased mobility. Compared to children with pauciarticular JRA, those with polyarticular or systemic JRA were significantly more likely to miss school, experience proble...

We compared two sources of behavior variability: decreased levels of reinforcement and reinforcement contingent on variability itself. In Experiment 1, four groups of rats were reinforced for different levels of response-sequence variability: one group was reinforced for low variability, two groups were reinforced for intermediate levels, and one group was reinforced for very high variability. ...

Previous research in a water-reinforced instrumental training situation with toads (Bufo arenarum) has shown that performance in both acquisition and extinction is poorer after partial, rather than continuous reinforcement training. In Experiment 1, the performance of a group receiving 24 trials on a 50% partial reinforcement schedule was poorer in acquisition and extinction than that of contin...

An analysis is given for the mechanical characteristics of multilayer elastomeric isolation bearings where the reinforcing elements-normally steel plates-are replaced by a fiber reinforcement. The fiber-reinforced isolator, in contrast to the steel-reinforced isolator (which is assumed to be rigid both in extension and flexure), is assumed to be flexible in extension, but completely without fle...

an experimental study is conducted on three ½ scales, single-story, single-bay, frame specimens. the first specimen was a reinforced concrete frame with solid-brick infill. the second specimen was a reinforced concrete frame with hollow clay perforated-brick infill. the last specimen was a reinforced concrete frame without any infill. these three specimens were tested by pseudostatic method. di...

concrete beams reinforced with glass fiber reinforced polymer (gfrp) bars exhibit large deflections and crack widths as compared with steel reinforced concrete beams due to the low modulus of elasticity of gfrp bars. different studies show that aci 318 equation for the effective moment of inertia ie does not predict deflection well for frp reinforced concrete beams. the purpose of this paper is...

the use of polymer composite (frp) as a reinforcement material for the repair and strengthening of important components of reinforced concrete structures, particularly columns, has found wide spread. in this study, the effect of intermediate layer on improving the confinement behavior of reinforced concrete columns has been investigated. to achieve the objectives of the study, 14 cylindrical re...